Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | BCL2L1 | Q07817 | 5/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 5/20 | 0.46 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.44 |
| ▸ | MLYCD | O95822 | 1/20 | 0.44 |
| ▸ | PTAFR | P25105 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018417 | 0.97 | NPC1 (0.46) | HSP90AA1BCL2L1MCL1P4HTMMLYCD | |
| SCHEMBL9018104 | 0.92 | BCL2L1 (0.48) | BCL2L1MCL1P4HTMNPC1RAB9A | |
| SCHEMBL9018225 | 0.91 | HSP90AA1 (0.47) | HSP90AA1P4HTMMLYCDPTAFRNPC1 | |
| SCHEMBL9018204 | 0.89 | NPC1 (0.46) | P4HTMNPC1RAB9ANAMPTSMN1; SMN2 | |
| SCHEMBL9018444 | 0.89 | SCN3A (0.50) | BCL2L1MCL1P4HTMNAMPTEPHX2 | |
| SCHEMBL9018065 | 0.89 | BCL2L1 (0.54) | BCL2L1MCL1NPC1RAB9ANAMPT | |
| SCHEMBL9018240 | 0.89 | BCL2L1 (0.52) | BCL2L1MCL1P4HTMNPC1RAB9A | |
| SCHEMBL9018412 | 0.88 | OPRM1 (0.48) | BCL2L1MCL1P4HTM | |
| SCHEMBL9018179 | 0.88 | NPC1 (0.49) | HSP90AA1P4HTMMLYCDNPC1RAB9A | |
| SCHEMBL9018206 | 0.88 | NPC1 (0.45) | HSP90AA1P4HTMMLYCDPTAFRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |