Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 2/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24028567 | 0.80 | GRIN1 (0.32) | — | |
| SCHEMBL17106339 | 0.71 | — | — | |
| SCHEMBL25970945 | 0.71 | ADRA2A (0.39) | ADRA2ABACE1SIGMAR1SMN1; SMN2TSHR | |
| SCHEMBL17106285 | 0.71 | — | — | |
| SCHEMBL24028568 | 0.70 | — | — | |
| SCHEMBL23835791 | 0.70 | MCL1 (0.31) | — | |
| SCHEMBL20741223 | 0.70 | ADRA2A (0.36) | ADRA2ABACE1SIGMAR1TSHROPRM1 | |
| SCHEMBL24170217 | 0.69 | ADRA2A (0.38) | ADRA2ABACE1SIGMAR1SMN1; SMN2TSHR | |
| SCHEMBL14803711 | 0.69 | ADRA2A (0.38) | ADRA2ABACE1SIGMAR1TSHRALDH1A1 | |
| SCHEMBL25966669 | 0.69 | ADRA2A (0.38) | ADRA2ABACE1SIGMAR1SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0361577-B1 | TETRAHYDRONAPHTHALENE AND INDANE DERIVATIVES | AKZO N.V. (NL) | 1993-05-05 | — | — | EP | disclosed |
| EP-0361577-A1 | Tetrahydronaphthalene and indane derivatives | AKZO N.V. (NL) | 1990-04-04 | — | — | EP | disclosed |