Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.56 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9320609 | 0.90 | THRB (0.56) | MEN1KMT2AKCNH2POLBGAA | |
| Hydrochloric Acid SCHEMBL9515573 | 0.89 | THRB (0.55) | MEN1KMT2AKCNH2POLBGAA | |
| SCHEMBL30089493 | 0.83 | MEN1 (0.63) | MEN1KMT2AKCNH2POLBGAA | |
| SCHEMBL10663590 | 0.82 | CA12 (0.67) | MEN1KMT2AALDH1A1SMN1; SMN2HSD11B1 | |
| SCHEMBL9426415 | 0.81 | MEN1 (1.00) | MEN1KMT2AKCNH2POLBGAA | |
| SCHEMBL17444686 | 0.81 | MEN1 (0.81) | MEN1KMT2AKCNH2POLBGAA | |
| SCHEMBL9321172 | 0.80 | THRB (0.54) | MEN1KMT2AKCNH2POLBGAA | |
| SCHEMBL5524549 | 0.79 | MEN1 (0.69) | MEN1KMT2AKCNH2POLBGAA | |
| SCHEMBL2927709 | 0.79 | MEN1 (0.73) | MEN1KMT2AKCNH2POLBGAA | |
| SCHEMBL27552111 | 0.79 | MEN1 (0.73) | MEN1KMT2AKCNH2POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0250361-B1 | Disubstituted piperazines | CIBA GEIGY AG (CH) | 1993-12-08 | — | — | EP | claimed |
| EP-0250361-A2 | Disubstituted piperazines | CIBA-GEIGY AG (CH) | 1987-12-23 | — | — | EP | claimed |
| EP-0250361-B1 | Disubstituted piperazines | CIBA GEIGY AG (CH) | 1993-12-08 | — | — | EP | disclosed |
| US-4804661-A | ANALGESICS | CIBA-GEIGY CORPORATION (US) | 1989-02-14 | — | — | US | disclosed |
| EP-0250361-A2 | Disubstituted piperazines | CIBA-GEIGY AG (CH) | 1987-12-23 | — | — | EP | disclosed |