SCHEMBL9516896

SCHEMBL9516896

Cc1ccc(C(c2ccc(C)cc2)C(C)C)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 7/20 0.47
TDP1 Q9NUW8 1/20 0.47
CHRNA7 P36544 1/20 0.46
ALOX5 P09917 1/20 0.39
CA7 P43166 2/20 0.36
ALDH1A1 P00352 2/20 0.36
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36
CA9 Q16790 1/20 0.36
CYP19A1 P11511 1/20 0.35
STAT3 P40763 1/20 0.35
CYP17A1 P05093 1/20 0.35
MEN1 O00255 1/20 0.34
GAA P10253 1/20 0.34
KMT2A Q03164 1/20 0.34
TSHR P16473 3/20 0.33
LMNA P02545 1/20 0.33
ALOX12 P18054 1/20 0.33
MAOA P21397 1/20 0.33
MAOB P27338 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9630224 0.88 CHRNA7 (0.43) ACHETDP1CHRNA7ALOX5CA7
SCHEMBL12789806 0.88 ACHE (0.59) ACHETDP1CHRNA7ALDH1A1CYP17A1
SCHEMBL21910185 0.88 TSHR (0.50) ACHETDP1CHRNA7MEN1KMT2A
SCHEMBL16504113 0.88 ACHE (0.59) ACHETDP1CHRNA7ALOX5ALDH1A1
SCHEMBL29101095 0.88 CHRNA7 (0.38) ACHETDP1CHRNA7ALOX5CYP19A1
SCHEMBL16447086 0.84 ACHE (0.57) ACHETDP1CHRNA7ALOX5CA7
SCHEMBL11849565 0.84 TSHR (0.62) ACHECHRNA7ALDH1A1TSHRLMNA
SCHEMBL10442181 0.84 ACHE (0.62) ACHETDP1CA7ALDH1A1CA1
SCHEMBL21910436 0.82 CYP2A6 (0.64) ACHEALDH1A1CA2CA9CYP19A1
SCHEMBL15617670 0.78 CHRNA7 (0.42) ACHETDP1CHRNA7ALOX5ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3814348-B1 SUBSTITUTED NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS BRISTOL MYERS SQUIBB CO (US) 2023-08-02 EP disclosed
WO-2021127554-A1 COMBINATIONS OF DGK INHIBITORS AND CHECKPOINT ANTAGONISTS BRISTOL-MYERS SQUIBB COMPANY (US) 2021-06-24 WO disclosed
EP-0305807-B1 Traction drive fluid IDEMITSU KOSAN CO (JP) 1993-12-22 EP disclosed
EP-0362673-B1 1,1-DICYCLOHEXYL CYCLOALKANE DERIVATIVE, METHOD FOR THE PREPARATION THEREOF AND TRACTION-DRIVE FLUID CONTAINING THE SAME IDEMITSU KOSAN COMPANY LIMITED (JP) 1993-07-28 EP disclosed
US-5107041-A 1,1-DICYCLOHEXYL CYCLOALKANE DERIVATIVE, METHOD FOR THE PREPARATION THEREOF AND TRACTION-DRIVE FLUID CONTAINING THE SAME IDEMITSU KOSAN CO., LTD. (JP) 1992-04-21 US disclosed
US-4975215-A Hydrogenated dimers, trimers or polymers of terpenes; heat and cold resistance; low viscosity IDEMITSU KOSAN CO., LTD. (JP) 1990-12-04 US disclosed
EP-0362673-A1 1,1-dicyclohexyl cycloalkane derivative, method for the preparation thereof and traction-drive fluid containing the same IDEMITSU KOSAN COMPANY LIMITED (JP) 1990-04-11 EP disclosed
EP-0305807-A2 Traction drive fluid IDEMITSU KOSAN COMPANY LIMITED (JP) 1989-03-08 EP disclosed