Acetic Acid

Acetic Acid

SCHEMBL9516924

CC(=O)O.O=C(O)O.[NaH].[NaH]

nearest known ligand 0.78

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Known targets — ChEMBL curated mechanism

ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FFAR3 O14843 2/20 0.78
LCK P06239 1/20 0.78
FYN P06241 1/20 0.78
CA1 P00915 3/20 0.56
CA2 P00918 2/20 0.56
CA9 Q16790 1/20 0.56
LMNA P02545 3/20 0.50
TSHR P16473 2/20 0.46
THPO P40225 1/20 0.46
ALOX15 P16050 1/20 0.42
BLM P54132 1/20 0.42
PMP22 Q01453 1/20 0.42
ALDH1A1 P00352 5/20 0.36
TDP1 Q9NUW8 1/20 0.36
KDM4E B2RXH2 1/20 0.36
PTGS1 P23219 1/20 0.36
MMP12 P39900 1/20 0.36
CA4 P22748 1/20 0.36
SLC15A2 Q16348 1/20 0.35
TP53 P04637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetic Acid SCHEMBL9806973 1.00
Acetic Acid SCHEMBL26969214 1.00 FFAR3 (0.78) FFAR3LCKFYNCA1CA2
Acetic Acid SCHEMBL27623470 0.95 FFAR3 (0.70) FFAR3LCKFYNCA1CA2
Acetic Acid SCHEMBL10704268 0.95 FFAR3 (0.70) FFAR3LCKFYNCA1CA2
Acetic Acid SCHEMBL6799505 0.95 FFAR3 (0.70) FFAR3LCKFYNCA1CA2
Acetic Acid SCHEMBL16431962 0.95 FFAR3 (0.70) FFAR3LCKFYNCA1CA2
Acetic Acid SCHEMBL20137312 0.95 FFAR3 (0.70) FFAR3LCKFYNCA1CA2
Acetic Acid SCHEMBL3714199 0.95 FFAR3 (0.70) FFAR3LCKFYNCA1CA2
Acetic Acid SCHEMBL9136601 0.95 FFAR3 (0.70) FFAR3LCKFYNCA1CA2
Acetic Acid SCHEMBL6264986 0.94 FFAR3 (0.88) FFAR3LCKFYNCA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5178167-A Cigarettes and fuels R. J. REYNOLDS TOBACCO COMPANY (US) 1993-01-12 US claimed
EP-0010834-A1 Method of sintering beta-alumina ceramic bodies, encapsulation chamber for use in such a method, and method of manufacturing such a chamber FORD MOTOR COMPANY LIMITED (GB) 1980-05-14 EP claimed
EP-3308647-A1 AGROCHEMICAL COMPOSITIONS FOR REDUCING AGROCHEMICAL RESIDUES Rotam Agrochem International Co., Ltd (CN) 2018-04-18 EP disclosed
EP-2816895-B1 AGROCHEMICAL COMPOSITIONS FOR REDUCING AGROCHEMICAL RESIDUES ROTAM AGROCHEM INT CO LTD (CN) 2017-12-27 EP disclosed
CN-107430236-A POLARIZING PLATE AND METHOD FOR PRODUCING SAME 日东电工株式会社 2017-12-01 CN disclosed
CN-107430235-A Polarizer, polarizing plate and method for producing polarizer 日东电工株式会社 2017-12-01 CN disclosed
CN-107206761-A Multilayer film 株式会社可乐丽 2017-09-26 CN disclosed
EP-0384798-B1 LIMULUS TEST-POSITIVE PLANT GLYCOLIPID, AND METHOD OF STIMULATING THE IMMUNO SYSTEM OF AN ANIMAL Soma, Gen-Ichiro (JP) 1993-08-11 EP disclosed
US-4739066-A HYPOTENSIVE AGENTS, ANGIOTENSIN INHIBITORS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1988-04-19 US disclosed
US-4638000-A HYPOTENSIVES, ANGIOTENSIN INHIBITORS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1987-01-20 US disclosed
EP-0156455-A2 Condensed seven-membered ring compounds, their production and use Takeda Chemical Industries, Ltd. (JP) 1985-10-02 EP disclosed