Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20812406 | 0.81 | HPGD (0.68) | EPHX2KMT2AALDH1A1MEN1NPC1 | |
| SCHEMBL5165363 | 0.80 | MEN1 (0.51) | EPHX2KMT2AALDH1A1MEN1NPC1 | |
| SCHEMBL19643861 | 0.79 | POLB (0.67) | EPHX2KMT2AALDH1A1MEN1NPC1 | |
| Ammonia Solution, Strong SCHEMBL5306550 | 0.79 | MEN1 (0.50) | EPHX2KMT2AALDH1A1MEN1NPC1 | |
| SCHEMBL5162733 | 0.79 | NPC1 (0.57) | EPHX2KMT2AALDH1A1MEN1NPC1 | |
| SCHEMBL2752183 | 0.79 | EPHX1 (0.67) | EPHX2KMT2AALDH1A1MEN1POLB | |
| SCHEMBL2317574 | 0.78 | SIGMAR1 (0.76) | — | |
| SCHEMBL2751915 | 0.77 | SIGMAR1 (0.67) | EPHX2KMT2AALDH1A1MEN1POLB | |
| SCHEMBL5051924 | 0.77 | EPHX2 (1.00) | EPHX2KMT2AALDH1A1MEN1NPC1 | |
| SCHEMBL3397254 | 0.77 | EPHX2 (1.00) | EPHX2KMT2AALDH1A1MEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0552386-A1 | 2-Amino-3 or 6-methoxycyclohexyl amide derivatives | WARNER-LAMBERT COMPANY (US) | 1993-07-28 | — | — | EP | disclosed |
| EP-0380063-B1 | 1,2-CYCLOHEXYLAMINOARYL AMIDES USEFUL AS ANALGESIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1993-07-21 | — | — | EP | disclosed |
| US-5051428-A | 2-amino-4 or 5-methoxycyclohexyl amides useful as analgesics | WARNER-LAMBERT COMPANY (US) | 1991-09-24 | — | — | US | disclosed |
| US-5019588-A | Nonhabit-forming analgeiscs | WARNER-LAMBERT COMPANY (US) | 1991-05-28 | — | — | US | disclosed |
| EP-0372466-A2 | 2-Amino-4 or 5-methoxycyclohexyl amides useful as analgesics | WARNER-LAMBERT COMPANY (US) | 1990-06-13 | — | — | EP | disclosed |
| US-4906655-A | Novel 1,2-cyclohexylaminoaryl amides useful as analgesic agents | WARNER-LAMBERT COMPANY (US) | 1990-03-06 | — | — | US | disclosed |
| US-4463013-A | Oxygen substituted amino-cyclohexyl-benzeneacetamides and -benzamides as water diuretic drugs | THE UPJOHN COMPANY (US) | 1984-07-31 | — | — | US | disclosed |