Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 10/20 | 0.48 |
| ▸ | PTGDR | Q13258 | 8/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PDE2A | O00408 | 7/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1255235 | 0.88 | PDE2A (0.50) | TBXA2RPTGDRMEN1ALDH1A1CYP3A4 | |
| SCHEMBL1254584 | 0.84 | PDE2A (0.55) | TBXA2RPTGDRPDE2A | |
| SCHEMBL1255659 | 0.84 | PDE2A (0.55) | TBXA2RPTGDRPDE2A | |
| SCHEMBL5420470 | 0.81 | PTGDR (0.48) | TBXA2RPTGDRPDE2AS1PR1 | |
| SCHEMBL4093843 | 0.81 | PTGDR (0.48) | TBXA2RPTGDRPDE2AS1PR1 | |
| SCHEMBL9019672 | 0.81 | BRD3 (0.60) | TBXA2RS1PR1 | |
| SCHEMBL10413574 | 0.79 | TBXA2R (0.42) | TBXA2RPTGDRMEN1ALDH1A1CYP3A4 | |
| SCHEMBL29141418 | 0.78 | S1PR1 (0.47) | S1PR1 | |
| SCHEMBL29141438 | 0.78 | S1PR1 (0.47) | S1PR1 | |
| SCHEMBL30762335 | 0.78 | S1PR1 (0.47) | S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-1070462-A | — | — | None | — | — | JP | disclosed |
| EP-0209435-B1 | Hydroxyalkoxy-4-phenylpropyl indole derivatives, their salts, process and intermediates for their preparation, use as medicines and compositions containing them | ROUSSEL UCLAF (FR) | 1993-11-24 | — | — | EP | disclosed |
| EP-0239306-B1 | TETRAHYDROCARBAZOLE ESTERS | MERCK FROSST CANADA INC. (CA) | 1993-06-02 | — | — | EP | disclosed |
| EP-0234708-B1 | TETRAHYDROCARBAZOLE 1-ALKANOIC ACIDS | MERCK FROSST CANADA INC. (CA) | 1991-02-27 | — | — | EP | disclosed |
| US-4940719-A | Tetrahydrocarbazole esters, pharmaceutical compositions and use | MERCK FROSST CANADA, INC. (CA) | 1990-07-10 | — | — | US | disclosed |
| EP-0310179-A2 | Tetrahydrocarbazole esters | MERCK FROSST CANADA INC. (CA) | 1989-04-05 | — | — | EP | disclosed |
| EP-0307077-A1 | Tetrahydrocarbazoles for the improvement of cyclosporin therapy | MERCK FROSST CANADA INC. (CA) | 1989-03-15 | — | — | EP | disclosed |
| US-4808608-A | ANTIALLERGENS, HYPOTENSIVE AGENT, ANTICOAGULANT | MERCK & CO., INC. (US) | 1989-02-28 | — | — | US | disclosed |
| EP-0300676-A2 | Tetrahydrocarbazole 1-alkanoic acids | MERCK FROSST CANADA INC. (CA) | 1989-01-25 | — | — | EP | disclosed |
| EP-0239306-A2 | Tetrahydrocarbazole esters | MERCK FROSST CANADA INC. (CA) | 1987-09-30 | — | — | EP | disclosed |
| EP-0234708-A1 | Tetrahydrocarbazole 1-alkanoic acids | MERCK FROSST CANADA INC. (CA) | 1987-09-02 | — | — | EP | disclosed |