Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD3 | Q15059 | 9/20 | 0.60 |
| ▸ | S1PR1 | P21453 | 8/20 | 0.56 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.55 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.50 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5421567 | 0.93 | S1PR1 (0.59) | BRD3S1PR1MAPKAPK2S1PR4ADORA3 | |
| SCHEMBL30762338 | 0.93 | S1PR1 (0.59) | BRD3S1PR1MAPKAPK2S1PR4ADORA3 | |
| SCHEMBL29141416 | 0.93 | S1PR1 (0.59) | BRD3S1PR1MAPKAPK2S1PR4ADORA3 | |
| SCHEMBL5088953 | 0.93 | S1PR1 (0.59) | BRD3S1PR1MAPKAPK2S1PR4ADORA3 | |
| SCHEMBL9459050 | 0.86 | SIRT1 (0.62) | S1PR1MAPKAPK2S1PR4ADORA3S1PR5 | |
| SCHEMBL6692543 | 0.86 | S1PR1 (0.53) | BRD3S1PR1MAPKAPK2S1PR4ADORA3 | |
| SCHEMBL9019716 | 0.83 | BRD3 (0.55) | BRD3S1PR1MAPKAPK2 | |
| SCHEMBL832934 | 0.82 | SIRT1 (0.60) | BRD3S1PR1MAPKAPK2TBXA2R | |
| SCHEMBL1872852 | 0.81 | SIRT1 (0.73) | BRD3MAPKAPK2 | |
| SCHEMBL9518113 | 0.81 | TBXA2R (0.48) | S1PR1TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0496237-B1 | N-imidazolyl derivatives of substituted tetrahydrocarbazole and cyclohept[b]indole | PHARMACIA SPA (IT) | 1996-02-14 | — | — | EP | disclosed |
| US-5238953-A | Thromboxane a2 antagonist | FARMITALIA CARLO ERBA S.R.L. (IT) | 1993-08-24 | — | — | US | disclosed |
| EP-0496237-A2 | N-imidazolyl derivatives of substituted tetrahydrocarbazole and cyclohept[b]indole | PHARMACIA S.p.A. (IT) | 1992-07-29 | — | — | EP | disclosed |
| EP-0234708-B1 | TETRAHYDROCARBAZOLE 1-ALKANOIC ACIDS | MERCK FROSST CANADA INC. (CA) | 1991-02-27 | — | — | EP | disclosed |
| EP-0307077-A1 | Tetrahydrocarbazoles for the improvement of cyclosporin therapy | MERCK FROSST CANADA INC. (CA) | 1989-03-15 | — | — | EP | disclosed |
| US-4808608-A | ANTIALLERGENS, HYPOTENSIVE AGENT, ANTICOAGULANT | MERCK & CO., INC. (US) | 1989-02-28 | — | — | US | disclosed |
| EP-0300676-A2 | Tetrahydrocarbazole 1-alkanoic acids | MERCK FROSST CANADA INC. (CA) | 1989-01-25 | — | — | EP | disclosed |
| EP-0234708-A1 | Tetrahydrocarbazole 1-alkanoic acids | MERCK FROSST CANADA INC. (CA) | 1987-09-02 | — | — | EP | disclosed |