Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 2/20 | 0.35 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4334244 | 0.85 | MGAM (0.46) | MGAMGAASIMGAM2FAAH | |
| SCHEMBL4334241 | 0.79 | MGAM (0.36) | MGAMGAASIMGAM2FAAH | |
| SCHEMBL2885490 | 0.79 | GAA (0.46) | MGAMGAASIMGAM2FAAH | |
| SCHEMBL9518326 | 0.78 | MGAM (0.34) | MGAMGAASIMGAM2FAAH | |
| SCHEMBL12296672 | 0.74 | NAAA (0.50) | MGAMGAASIMGAM2 | |
| SCHEMBL8830943 | 0.72 | HTR2C (0.35) | — | |
| SCHEMBL3200441 | 0.72 | CA4 (0.43) | CA4MGAMGAASIMGAM2 | |
| SCHEMBL1555575 | 0.72 | CYP2C19 (0.54) | FAAH | |
| SCHEMBL3190793 | 0.72 | MGAM (0.42) | CA4MGAMGAASIMGAM2 | |
| Lithium Ion SCHEMBL3193348 | 0.72 | MGAM (0.42) | CA4MGAMGAASIMGAM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0516729-B1 | N-PHENYL N-ALKOXYCARBONYLALKYL GLYCINAMIDES, PREPARATION METHOD AND DRUGS CONTAINING THEM | RHONE POULENC RORER SA (FR) | 1993-12-29 | — | — | EP | disclosed |
| EP-0397556-B1 | N-Phenyl amides, methods for their preparation and medicaments containing them | RHONE POULENC SANTE (FR) | 1993-10-20 | — | — | EP | disclosed |
| EP-0300657-B1 | 4-SUBSTITUTED 3-OXOBUTANOATE ESTER DERIVATIVES | MERCK & CO. INC. (US) | 1993-03-31 | — | — | EP | disclosed |
| EP-0300249-B1 | 7-[1H-pyrrol-3-yl]-substituted 3,5-dihydroxy-heptane acids, their corresponding delta-lactones and salts, processes for their manufacture, their use as medicines, pharmaceutical preparations and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-02-03 | — | — | EP | disclosed |
| EP-0397556-A1 | N-Phenyl amides, methods for their preparation and medicaments containing them | RHONE-POULENC SANTE (FR) | 1990-11-14 | — | — | EP | disclosed |
| EP-0300657-A2 | 4-substituted 3-oxobutanoate ester derivatives | MERCK & CO. INC. (US) | 1989-01-25 | — | — | EP | disclosed |