Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4A11 | Q02928 | 6/20 | 0.54 |
| ▸ | CYP4F2 | P78329 | 5/20 | 0.54 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | ACACB | O00763 | 1/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | KDM6B | O15054 | 1/20 | 0.40 |
| ▸ | KDM5C | P41229 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.40 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4871286 | 0.91 | CYP4A11 (0.54) | CYP4A11CYP4F2PARP1ALDH1A1AR | |
| SCHEMBL22335931 | 0.89 | CYP4A11 (0.57) | CYP4A11CYP4F2PARP1ALDH1A1AR | |
| SCHEMBL29479667 | 0.87 | PARP1 (0.50) | PARP1ALDH1A1ARACACBLOXL2 | |
| SCHEMBL502256 | 0.87 | PARP1 (0.50) | PARP1ALDH1A1ARACACBLOXL2 | |
| SCHEMBL30600807 | 0.85 | SMYD3 (0.52) | PARP1ALDH1A1ARACACBMAPK1 | |
| SCHEMBL5234628 | 0.85 | SMYD3 (0.52) | PARP1ALDH1A1ARACACBMAPK1 | |
| SCHEMBL30996114 | 0.84 | PARP1 (0.46) | CYP4A11CYP4F2PARP1ALDH1A1AR | |
| SCHEMBL9602508 | 0.84 | CYP4F2 (0.47) | CYP4A11CYP4F2ALDH1A1MAPK1KDM4E | |
| SCHEMBL30996113 | 0.84 | FFAR1 (0.47) | PARP1ALDH1A1ARACACBKDM4E | |
| SCHEMBL30112067 | 0.83 | AR (0.54) | CYP4A11CYP4F2PARP1ALDH1A1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1022244-C | Tetrazole excitatory amino acid receptor antagonists | LILLY CO ELI (US) | 1993-09-29 | — | — | CN | disclosed |
| EP-0330353-B1 | TETRAZOLE EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1993-04-07 | — | — | EP | disclosed |
| US-4968678-A | NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY (US) | 1990-11-06 | — | — | US | disclosed |
| EP-0330353-A1 | Tetrazole excitatory amino acid receptor antagonists | ELI LILLY AND COMPANY (US) | 1989-08-30 | — | — | EP | disclosed |
| CN-1035114-A | TETRAZOLE EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1989-08-30 | — | — | CN | disclosed |