Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.51 |
| ▸ | ELANE | P08246 | 1/20 | 0.47 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9056754 | 0.83 | MEN1 (0.47) | CYP19A1ELANEP2RX4KDM4ECYP1A2 | |
| Acetic Acid SCHEMBL9519258 | 0.78 | CYP19A1 (0.78) | CYP19A1P2RX4KDM4ECYP1A2CYP2C9 | |
| SCHEMBL8802009 | 0.77 | MEN1 (0.46) | CYP19A1ELANEKDM4EHSD17B10L3MBTL1 | |
| SCHEMBL8388094 | 0.77 | MEN1 (0.48) | KDM4EHSD17B10L3MBTL1PTGS2MAPT | |
| SCHEMBL7234016 | 0.77 | MAPT (0.55) | L3MBTL1MAPTALDH1A1MTNR1AMTNR1B | |
| SCHEMBL9056373 | 0.76 | ELANE (0.57) | CYP19A1ELANEP2RX4KDM4EMAPT | |
| SCHEMBL9518406 | 0.76 | FABP4 (0.66) | CYP19A1P2RX4KDM4ECYP1A2CYP2C9 | |
| SCHEMBL9056374 | 0.76 | ELANE (0.47) | ELANEKDM4EGFERMAPTALDH1A1 | |
| SCHEMBL8388034 | 0.76 | HDAC6 (0.44) | P2RX4KDM4EMAPTALDH1A1MITF | |
| SCHEMBL8387072 | 0.76 | PTGES2 (0.42) | KDM4ECYP1A2CYP2C9CYP2C19HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0239306-B1 | TETRAHYDROCARBAZOLE ESTERS | MERCK FROSST CANADA INC. (CA) | 1993-06-02 | — | — | EP | disclosed |
| EP-0234708-B1 | TETRAHYDROCARBAZOLE 1-ALKANOIC ACIDS | MERCK FROSST CANADA INC. (CA) | 1991-02-27 | — | — | EP | disclosed |
| US-4940719-A | Tetrahydrocarbazole esters, pharmaceutical compositions and use | MERCK FROSST CANADA, INC. (CA) | 1990-07-10 | — | — | US | disclosed |
| EP-0310179-A2 | Tetrahydrocarbazole esters | MERCK FROSST CANADA INC. (CA) | 1989-04-05 | — | — | EP | disclosed |
| US-4808608-A | ANTIALLERGENS, HYPOTENSIVE AGENT, ANTICOAGULANT | MERCK & CO., INC. (US) | 1989-02-28 | — | — | US | disclosed |
| EP-0300676-A2 | Tetrahydrocarbazole 1-alkanoic acids | MERCK FROSST CANADA INC. (CA) | 1989-01-25 | — | — | EP | disclosed |
| EP-0239306-A2 | Tetrahydrocarbazole esters | MERCK FROSST CANADA INC. (CA) | 1987-09-30 | — | — | EP | disclosed |
| EP-0234708-A1 | Tetrahydrocarbazole 1-alkanoic acids | MERCK FROSST CANADA INC. (CA) | 1987-09-02 | — | — | EP | disclosed |