Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | BRD4 | O60885 | 10/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.39 |
| ▸ | CTSV | O60911 | 2/20 | 0.36 |
| ▸ | CTSL | P07711 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.34 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9519379 | 0.89 | ALDH1A1 (0.62) | ALDH1A1BRD4SMN1; SMN2GPR84MEN1 | |
| Bromide SCHEMBL9518983 | 0.88 | ALDH1A1 (0.60) | ALDH1A1BRD4SMN1; SMN2GPR84MEN1 | |
| SCHEMBL16414571 | 0.83 | BRD4 (0.54) | ALDH1A1BRD4SMN1; SMN2GPR84CTSV | |
| SCHEMBL3836008 | 0.73 | ALDH1A1 (1.00) | ALDH1A1BRD4SMN1; SMN2MEN1POLB | |
| SCHEMBL9553269 | 0.72 | HRH3 (0.43) | ALDH1A1SMN1; SMN2MEN1MAPTRAB9A | |
| SCHEMBL9552525 | 0.72 | HRH3 (0.43) | ALDH1A1SMN1; SMN2MEN1MAPTRAB9A | |
| SCHEMBL16414517 | 0.70 | BRD4 (0.67) | ALDH1A1BRD4SMN1; SMN2CTSVCTSL | |
| SCHEMBL16414580 | 0.70 | BRD4 (0.67) | ALDH1A1BRD4SMN1; SMN2MEN1POLB | |
| SCHEMBL9135033 | 0.70 | MAOB (0.44) | ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL16415205 | 0.70 | SMN1; SMN2 (0.92) | ALDH1A1BRD4SMN1; SMN2IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0279598-B1 | ARYLPIPERAZINYL-ALKYLENE-PHENYL-HETEROCYCLIC COMPOUNDS | PFIZER INC. (US) | 1993-09-15 | — | — | EP | disclosed |
| US-4891375-A | Arylpiperazinyl-alkylene-phenyl-heterocyclic compounds | PFIZER INC. (US) | 1990-01-02 | — | — | US | disclosed |
| EP-0279598-A2 | Arylpiperazinyl-alkylene-phenyl-heterocyclic compounds | PFIZER INC. (US) | 1988-08-24 | — | — | EP | disclosed |