Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ITGB1 | P05556 | 5/20 | 0.38 |
| ▸ | ITGA5 | P08648 | 5/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.38 |
| ▸ | ITGAV | P06756 | 4/20 | 0.38 |
| ▸ | ITGB5 | P18084 | 3/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10713467 | 1.00 | POLB (0.41) | POLBITGB1ITGA5ITGB3ITGAV | |
| SCHEMBL9519952 | 0.90 | POLB (0.41) | POLBITGB1ITGA5ITGB3ITGAV | |
| SCHEMBL9795055 | 0.89 | POLB (0.41) | POLBITGB1ITGA5ITGB3ITGAV | |
| SCHEMBL9519482 | 0.89 | POLB (0.40) | POLBITGB1ITGA5ITGB3ITGAV | |
| SCHEMBL9520991 | 0.89 | POLB (0.40) | POLBITGB1ITGA5ITGB3ITGAV | |
| SCHEMBL9795078 | 0.88 | POLB (0.40) | POLBITGB1ITGA5ITGB3ITGAV | |
| SCHEMBL9795011 | 0.87 | POLB (0.40) | POLBITGB1ITGA5ITGB3ITGAV | |
| SCHEMBL9519206 | 0.86 | ITGB1 (0.40) | POLBITGB1ITGA5ITGB3ITGAV | |
| SCHEMBL9794963 | 0.86 | POLB (0.37) | POLBITGB1ITGA5ITGB3ITGAV | |
| SCHEMBL9369429 | 0.86 | POLB (0.44) | POLBITGB1ITGA5ITGB3ITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0272456-B1 | 3-Pyrrolidinylthio-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds and processes for the preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-03-31 | — | — | EP | disclosed |
| US-4822787-A | 3-pyrrolidinylthio-1-azabicyclo(3.2.0)-hept-2-ene-2-carboxylic acid compounds and antimicrobial activity thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-04-18 | — | — | US | disclosed |
| EP-0272456-A1 | 3-Pyrrolidinylthio-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds and processes for the preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-06-29 | — | — | EP | disclosed |