Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 4/20 | 0.39 |
| ▸ | ITGAV | P06756 | 4/20 | 0.39 |
| ▸ | ITGA5 | P08648 | 4/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.39 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | CTSG | P08311 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9520991 | 1.00 | POLB (0.40) | POLBCYP2C19SMN1; SMN2ITGB3ITGB1 | |
| SCHEMBL9519952 | 0.92 | POLB (0.41) | POLBSMN1; SMN2ITGB3ITGB1ITGAV | |
| SCHEMBL9795055 | 0.91 | POLB (0.41) | POLBITGB3ITGB1ITGAVITGA5 | |
| SCHEMBL9519206 | 0.90 | ITGB1 (0.40) | POLBCYP2C19SMN1; SMN2ITGB3ITGB1 | |
| SCHEMBL10713467 | 0.89 | POLB (0.41) | POLBCYP2C19ITGB3ITGB1ITGAV | |
| SCHEMBL9519289 | 0.89 | POLB (0.41) | POLBCYP2C19ITGB3ITGB1ITGAV | |
| SCHEMBL9519756 | 0.88 | POLB (0.40) | POLBCYP2C19SMN1; SMN2ITGB3ITGB1 | |
| SCHEMBL9369429 | 0.88 | POLB (0.44) | POLBSMN1; SMN2ITGB3ITGB1ITGAV | |
| SCHEMBL9369434 | 0.88 | POLB (0.44) | POLBSMN1; SMN2ITGB3ITGB1ITGAV | |
| SCHEMBL9519220 | 0.87 | ALDH1A1 (0.37) | MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0272456-B1 | 3-Pyrrolidinylthio-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds and processes for the preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-03-31 | — | — | EP | disclosed |
| US-4822787-A | 3-pyrrolidinylthio-1-azabicyclo(3.2.0)-hept-2-ene-2-carboxylic acid compounds and antimicrobial activity thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-04-18 | — | — | US | disclosed |
| EP-0272456-A1 | 3-Pyrrolidinylthio-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds and processes for the preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-06-29 | — | — | EP | disclosed |