Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | WDR5 | P61964 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzene SCHEMBL28266121 | 0.87 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DL3MBTL1 | |
| SCHEMBL247446 | 0.87 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DL3MBTL1 | |
| SCHEMBL8526041 | 0.82 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4821604 | 0.82 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8526044 | 0.82 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL13985939 | 0.82 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4821599 | 0.82 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL17412169 | 0.80 | RECQL (0.61) | MAPTSMN1; SMN2WDR5NPC1RAB9A | |
| SCHEMBL11753040 | 0.80 | SMN1; SMN2 (0.48) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL28724952 | 0.80 | ALDH1A1 (0.40) | PDE4APDE4BPDE4CPDE4DMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0299379-B1 | PENTADIENAMIDE PAF-ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1993-04-21 | — | — | EP | disclosed |
| US-4975438-A | ANTICOAGULANT | HOFFMANN-LA ROCHE INC. (US) | 1990-12-04 | — | — | US | disclosed |
| EP-0299379-A1 | Pentadienamide PAF-antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1989-01-18 | — | — | EP | disclosed |
| US-4788206-A | CARDIOVASCULAR DISORDERS, PLATELETS | HOFFMANN-LA ROCHE INC. (US) | 1988-11-29 | — | — | US | disclosed |