Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27316042 | 0.69 | CYP3A4 (0.33) | TSHRALDH1A1CYP3A4TDP1 | |
| SCHEMBL487510 | 0.67 | ALDH1A1 (0.54) | TSHRALDH1A1CYP3A4RECQLNPC1 | |
| SCHEMBL7229176 | 0.67 | MAPT (0.38) | TSHRALDH1A1CYP3A4RECQLNPC1 | |
| SCHEMBL7224105 | 0.66 | TSHR (0.37) | TSHRALDH1A1CYP3A4RECQLNPC1 | |
| SCHEMBL9350062 | 0.64 | DAO (0.32) | TSHR | |
| SCHEMBL9107706 | 0.63 | ALDH1A1 (0.60) | TSHRALDH1A1CYP3A4RECQLTDP1 | |
| SCHEMBL13176891 | 0.63 | TSHR (0.60) | TSHRALDH1A1CYP3A4RECQLTDP1 | |
| SCHEMBL30040348 | 0.63 | ALDH1A1 (0.60) | TSHRALDH1A1CYP3A4RECQLTDP1 | |
| SCHEMBL8745991 | 0.60 | TSHR (0.56) | TSHRALDH1A1CYP3A4RECQLTDP1 | |
| SCHEMBL28531673 | 0.60 | ALDH1A1 (0.50) | TSHRALDH1A1CYP3A4RECQLNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0408713-B1 | PHENYLSULPHONE DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-05-19 | — | — | EP | disclosed |
| EP-0408713-A1 | PHENYLSULPHONE DERIVATIVES. | ICI PLC (GB) | 1991-01-23 | — | — | EP | disclosed |
| WO-1990008761-A1 | PHENYLSULPHONE DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-08-09 | — | — | WO | disclosed |