Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.38 |
| ▸ | WNT3A | P56704 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9520172 | 0.82 | PIM1 (0.49) | PPARGHDAC8 | |
| SCHEMBL9520174 | 0.82 | PIM1 (0.49) | PPARGHDAC8 | |
| SCHEMBL9523037 | 0.79 | PPARG (0.46) | PPARGPPARA | |
| SCHEMBL4748563 | 0.75 | PPARG (0.49) | PPARGPPARA | |
| SCHEMBL9520625 | 0.75 | PPARG (0.45) | PPARG | |
| SCHEMBL26313659 | 0.73 | PPARG (0.57) | PPARGPPARAHDAC1HDAC8HDAC6 | |
| SCHEMBL9426717 | 0.73 | PPARA (0.38) | PPARGPPARACTNNB1WNT3A | |
| SCHEMBL5229185 | 0.72 | HDAC1 (0.48) | PPARGPPARAHDAC1HDAC8HDAC6 | |
| SCHEMBL5795341 | 0.70 | KDM4E (0.54) | PPARGPPARA | |
| SCHEMBL14672185 | 0.70 | HDAC1 (0.44) | PPARGPPARAHDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0332332-B1 | HYPOGLYCEMIC THIAZOLIDINEDIONE DERIVATIVES | PFIZER INC. (US) | 1993-03-31 | — | — | EP | disclosed |
| US-5130379-A | Anticholesterol agents and antidiabetic agents | PFIZER INC. (US) | 1992-07-14 | — | — | US | disclosed |
| US-5036079-A | Anticholesterol | PFIZER INC. (US) | 1991-07-30 | — | — | US | disclosed |
| WO-1991003474-A1 | HYPOGLYCEMIC THIAZOLIDINEDIONE DERIVATIVES | PFIZER INC. (US) | 1991-03-21 | — | — | WO | disclosed |
| EP-0332332-A1 | Hypoglycemic thiazolidinedione derivatives | PFIZER INC. (US) | 1989-09-13 | — | — | EP | disclosed |