Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.40 |
| ▸ | GRIN2D known ✓ | O15399 | 1/20 | 0.38 |
| ▸ | GRIN2A known ✓ | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2B known ✓ | Q13224 | 1/20 | 0.38 |
| ▸ | GRIN2C known ✓ | Q14957 | 1/20 | 0.38 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.36 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | CTSA | P10619 | 1/20 | 0.38 |
| ▸ | UTS2R | Q9UKP6 | 4/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL9520794 | 1.00 | SLC13A5 (0.55) | SLC13A5CYP1A2KDM4EMEN1LMNA | |
| Citric Acid SCHEMBL9613830 | 0.82 | SLC13A5 (0.42) | SLC13A5CYP1A2KDM4EMEN1LMNA | |
| Citric Acid SCHEMBL9518970 | 0.78 | SLC13A5 (0.59) | SLC13A5CYP1A2KDM4EMEN1LMNA | |
| Citric Acid SCHEMBL9518963 | 0.78 | SLC13A5 (0.59) | SLC13A5CYP1A2KDM4EMEN1LMNA | |
| Citric Acid SCHEMBL9520803 | 0.76 | SLC13A5 (0.57) | SLC13A5CYP1A2KDM4EMEN1LMNA | |
| SCHEMBL10484411 | 0.75 | SLC13A5 (0.53) | SLC13A5CYP1A2KDM4EMEN1LMNA | |
| Decanoic Acid SCHEMBL9519013 | 0.74 | CYP1A2 (0.51) | CYP1A2LMNACYP2D6HDAC1UTS2R | |
| Decanoic Acid SCHEMBL9519009 | 0.74 | CYP1A2 (0.51) | CYP1A2LMNACYP2D6HDAC1UTS2R | |
| SCHEMBL27396500 | 0.70 | CYP1A2 (0.57) | SLC13A5CYP1A2CYP2D6HDAC1GRIN2D | |
| Citric Acid SCHEMBL10484280 | 0.69 | SLC13A5 (0.39) | SLC13A5CYP1A2KDM4EMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0318234-B1 | IMPROVEMENTS IN OR RELATING TO SELECTIVE SEROTONIN UPTAKE INHIBITORS | ELI LILLY AND COMPANY (US) | 1993-03-17 | — | — | EP | disclosed |
| US-4876282-A | ANTIDEPRESSANT, DIETETICS, ANTIALCOHOLISM AGENT | ELI LILLY AND COMPANY (US) | 1989-10-24 | — | — | US | disclosed |