Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.42 |
| ▸ | PPARA | Q07869 | 7/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 6/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9520931 | 1.00 | PIM1 (0.42) | PIM1PPARAPIM2NR1H4KDM4E | |
| SCHEMBL9721298 | 0.89 | NPC1 (0.41) | PPARAKDM4EPPARG | |
| SCHEMBL9721300 | 0.89 | NPC1 (0.41) | PPARAKDM4EPPARG | |
| SCHEMBL9520852 | 0.83 | PPARA (0.44) | PIM1PPARAPIM2NR1H4KDM4E | |
| SCHEMBL9520845 | 0.83 | PPARA (0.44) | PIM1PPARAPIM2NR1H4KDM4E | |
| SCHEMBL9521653 | 0.78 | PIM1 (0.50) | PIM1PPARAPIM2NR1H4PPARG | |
| SCHEMBL9521656 | 0.78 | PIM1 (0.50) | PIM1PPARAPIM2NR1H4PPARG | |
| SCHEMBL9521119 | 0.77 | PPARG (0.38) | PPARAPPARG | |
| SCHEMBL9521124 | 0.77 | PPARG (0.38) | PPARAPPARG | |
| SCHEMBL9879230 | 0.74 | PIK3CG (0.40) | PIM1PPARAPIM2NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0332332-B1 | HYPOGLYCEMIC THIAZOLIDINEDIONE DERIVATIVES | PFIZER INC. (US) | 1993-03-31 | — | — | EP | disclosed |
| US-5130379-A | Anticholesterol agents and antidiabetic agents | PFIZER INC. (US) | 1992-07-14 | — | — | US | disclosed |
| US-5036079-A | Anticholesterol | PFIZER INC. (US) | 1991-07-30 | — | — | US | disclosed |
| EP-0332332-A1 | Hypoglycemic thiazolidinedione derivatives | PFIZER INC. (US) | 1989-09-13 | — | — | EP | disclosed |