Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.59 |
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.59 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9523450 | 0.85 | HTR1A (0.70) | HTR1ASLC6A4 | |
| Hydrochloric Acid SCHEMBL9520889 | 0.80 | HTR1A (0.69) | HTR1ASLC6A4 | |
| Hydrochloric Acid SCHEMBL9521293 | 0.76 | HTR1A (0.63) | HTR1ASLC6A4SIGMAR1TAAR1 | |
| Hydrochloric Acid SCHEMBL9521599 | 0.74 | HTR1A (0.69) | HTR1ASLC6A4SIGMAR1TAAR1 | |
| Hydrochloric Acid SCHEMBL9520941 | 0.72 | SLC6A4 (0.80) | HTR1ASLC6A4 | |
| Bromide SCHEMBL9464934 | 0.71 | SLC6A4 (0.50) | HTR1ASLC6A4SIGMAR1TAAR1 | |
| SCHEMBL9715572 | 0.71 | HTR1A (0.88) | HTR1ASLC6A4 | |
| Hydrochloric Acid SCHEMBL9523522 | 0.70 | HTR1A (0.69) | HTR1ASLC6A4 | |
| Bromide SCHEMBL9522890 | 0.67 | ESR1 (0.54) | HTR1ASLC6A4 | |
| Bromide SCHEMBL9519869 | 0.67 | HTR1A (0.49) | HTR1ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0325963-B1 | 1-AMINOMETHYL-1,2,3,4-TETRAHYDRONAPHTHALENES AND -INDANES | ABBOTT LABORATORIES (US) | 1993-09-22 | — | — | EP | disclosed |
| US-5128362-A | Antidepressant, antiglaucoma | ABBOTT LABORATORIES (US) | 1992-07-07 | — | — | US | disclosed |
| US-5086074-A | Selective adrenergic receptor antagonists | ABBOTT LABORATORIES (US) | 1992-02-04 | — | — | US | disclosed |
| EP-0325963-A1 | 1-Aminomethyl-1,2,3,4-tetrahydronaphthalenes and -indanes | ABBOTT LABORATORIES (US) | 1989-08-02 | — | — | EP | disclosed |