Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 7/20 | 0.58 |
| ▸ | RARG | P13631 | 7/20 | 0.58 |
| ▸ | CYP26A1 | O43174 | 6/20 | 0.58 |
| ▸ | RARA | P10276 | 4/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.58 |
| ▸ | CYP26B1 | Q9NR63 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 4/20 | 0.36 |
| ▸ | RXRB | P28702 | 4/20 | 0.36 |
| ▸ | RXRG | P48443 | 4/20 | 0.36 |
| ▸ | PSIP1 | O75475 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9279402 | 0.85 | RARB (0.61) | RARBRARGCYP26A1RARACYP3A4 | |
| SCHEMBL9518109 | 0.82 | RARB (0.57) | RARBRARGCYP26A1RARACYP3A4 | |
| Etarotene SCHEMBL7794844 | 0.81 | RARB (0.67) | RARBRARGCYP26A1RARACYP3A4 | |
| Etarotene SCHEMBL7794840 | 0.81 | RARB (0.67) | RARBRARGCYP26A1RARACYP3A4 | |
| SCHEMBL9279401 | 0.79 | CYP26A1 (0.50) | RARBRARGCYP26A1RARACYP3A4 | |
| SCHEMBL9484589 | 0.77 | RARB (0.65) | RARBRARGCYP26A1RARACYP3A4 | |
| SCHEMBL9483828 | 0.75 | RARB (0.63) | RARBRARGCYP26A1RARACYP3A4 | |
| SCHEMBL10899364 | 0.75 | RARB (0.63) | RARBRARGCYP26A1RARACYP3A4 | |
| SCHEMBL9483603 | 0.75 | RARB (0.58) | RARBRARGCYP26A1RARACYP3A4 | |
| SCHEMBL9484092 | 0.75 | RARB (0.62) | RARBRARGCYP26A1RARACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0412387-B1 | Diarylacetylenes, their process and use | BASF AG (DE) | 1993-11-24 | — | — | EP | disclosed |
| US-5087637-A | Skin disorders | BASF AKTIENGESELLSCHAFT (DE) | 1992-02-11 | — | — | US | disclosed |