Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 7/20 | 0.58 |
| ▸ | RARG | P13631 | 7/20 | 0.58 |
| ▸ | CYP26A1 | O43174 | 5/20 | 0.58 |
| ▸ | RARA | P10276 | 5/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.58 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | RXRG | P48443 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | CYP26B1 | Q9NR63 | 4/20 | 0.40 |
| ▸ | PPARG | P37231 | 3/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | GNRHR | P30968 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9484092 | 0.84 | RARB (0.62) | RARBRARGCYP26A1RARACYP3A4 | |
| SCHEMBL9483769 | 0.82 | RARB (0.56) | RARBRARGCYP26A1RARACYP3A4 | |
| SCHEMBL9484589 | 0.80 | RARB (0.65) | RARBRARGCYP26A1RARACYP3A4 | |
| SCHEMBL10899364 | 0.79 | RARB (0.63) | RARBRARGCYP26A1RARACYP3A4 | |
| SCHEMBL9483828 | 0.79 | RARB (0.63) | RARBRARGCYP26A1RARACYP3A4 | |
| SCHEMBL8557385 | 0.79 | RARA (0.54) | RARBRARGCYP26A1RARARXRA | |
| SCHEMBL10515002 | 0.77 | CYP26A1 (0.70) | RARBRARGCYP26A1RARACYP3A4 | |
| SCHEMBL14425242 | 0.77 | RARB (0.61) | RARBRARGCYP26A1RARACYP3A4 | |
| SCHEMBL9485008 | 0.76 | CYP26A1 (0.60) | RARBRARGCYP26A1RARACYP3A4 | |
| SCHEMBL9485574 | 0.76 | RARB (0.60) | RARBRARGCYP26A1RARACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5256694-A | For skin disorders; carcinomas | BASF AKTIENGESELLSCHAFT (DE) | 1993-10-26 | — | — | US | disclosed |
| US-5126371-A | Precancerous skin conditions, acne, psoriasis | BASF AKTEINGESELLSCHAFT (DE) | 1992-06-30 | — | — | US | disclosed |
| US-4994489-A | Ester derivatives of diarylacetylenes, their compositions and their use in acne treatment | BASF AKTIENGESELLSCHAFT | 1991-02-19 | — | — | US | disclosed |
| EP-0176034-B1 | DIARYL ACETYLENES, THEIR PREPARATION AND USE | BASF Aktiengesellschaft (DE) | 1989-08-30 | — | — | EP | disclosed |
| US-4806558-A | Diarylacetylenes and their use in treating acne | BASF AKTIENGESELLSCHAFT (DE) | 1989-02-21 | — | — | US | disclosed |
| EP-0176034-A2 | Diaryl acetylenes, their preparation and use | BASF Aktiengesellschaft (DE) | 1986-04-02 | — | — | EP | disclosed |