Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 6/20 | 0.49 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | PPARG | P37231 | 5/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 3/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9521141 | 1.00 | PIM1 (0.49) | PIM1PIM2HPGDPPARGHDAC4 | |
| SCHEMBL9520097 | 0.93 | KDM4E (0.45) | PIM1PIM2HPGDPPARGPPARA | |
| SCHEMBL9520104 | 0.93 | KDM4E (0.45) | PIM1PIM2HPGDPPARGPPARA | |
| SCHEMBL9521653 | 0.90 | PIM1 (0.50) | PIM1PIM2PPARGHDAC4PPARA | |
| SCHEMBL9521656 | 0.90 | PIM1 (0.50) | PIM1PIM2PPARGHDAC4PPARA | |
| SCHEMBL9521889 | 0.88 | PTPN1 (0.43) | PIM1HPGDPPARGHDAC4HDAC8 | |
| SCHEMBL9521885 | 0.88 | PTPN1 (0.43) | PIM1HPGDPPARGHDAC4HDAC8 | |
| SCHEMBL9520639 | 0.86 | PIM1 (0.43) | PIM1PIM2HPGDHDAC4AKR1B1 | |
| SCHEMBL9520645 | 0.86 | PIM1 (0.43) | PIM1PIM2HPGDHDAC4AKR1B1 | |
| SCHEMBL9520174 | 0.83 | PIM1 (0.49) | PIM1PIM2HPGDPPARGHDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0332332-B1 | HYPOGLYCEMIC THIAZOLIDINEDIONE DERIVATIVES | PFIZER INC. (US) | 1993-03-31 | — | — | EP | disclosed |
| US-5130379-A | Anticholesterol agents and antidiabetic agents | PFIZER INC. (US) | 1992-07-14 | — | — | US | disclosed |
| US-5036079-A | Anticholesterol | PFIZER INC. (US) | 1991-07-30 | — | — | US | disclosed |
| WO-1991003474-A1 | HYPOGLYCEMIC THIAZOLIDINEDIONE DERIVATIVES | PFIZER INC. (US) | 1991-03-21 | — | — | WO | disclosed |