Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 3/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 8/20 | 0.44 |
| ▸ | PPARG | P37231 | 4/20 | 0.43 |
| ▸ | PPARA | Q07869 | 4/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9520104 | 1.00 | KDM4E (0.45) | KDM4EPIM1PIM2PIM3HPGD | |
| SCHEMBL9521141 | 0.93 | PIM1 (0.49) | KDM4EPIM1PIM2HPGDPPARG | |
| SCHEMBL9521137 | 0.93 | PIM1 (0.49) | KDM4EPIM1PIM2HPGDPPARG | |
| SCHEMBL9521885 | 0.90 | PTPN1 (0.43) | PIM1HPGDPPARGPPARA | |
| SCHEMBL9521889 | 0.90 | PTPN1 (0.43) | PIM1HPGDPPARGPPARA | |
| SCHEMBL9520385 | 0.90 | PPARG (0.41) | KDM4EPPARGPPARAPIK3CGKCNH2 | |
| SCHEMBL9520389 | 0.90 | PPARG (0.41) | KDM4EPPARGPPARAPIK3CGKCNH2 | |
| SCHEMBL9521656 | 0.88 | PIM1 (0.50) | PIM1PIM2PPARGPPARA | |
| SCHEMBL9521653 | 0.88 | PIM1 (0.50) | PIM1PIM2PPARGPPARA | |
| SCHEMBL9520639 | 0.86 | PIM1 (0.43) | PIM1PIM2HPGDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0332332-B1 | HYPOGLYCEMIC THIAZOLIDINEDIONE DERIVATIVES | PFIZER INC. (US) | 1993-03-31 | — | — | EP | disclosed |
| US-5130379-A | Anticholesterol agents and antidiabetic agents | PFIZER INC. (US) | 1992-07-14 | — | — | US | disclosed |
| US-5036079-A | Anticholesterol | PFIZER INC. (US) | 1991-07-30 | — | — | US | disclosed |
| WO-1991003474-A1 | HYPOGLYCEMIC THIAZOLIDINEDIONE DERIVATIVES | PFIZER INC. (US) | 1991-03-21 | — | — | WO | disclosed |
| WO-1989008651-A1 | HYPOGLYCEMIC THIAZOLIDINEDIONE DERIVATIVES | PFIZER INC. (US) | 1989-09-21 | — | — | WO | disclosed |