Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 2/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | JAK1 | P23458 | 2/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | CFB | P00751 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TERT | O14746 | 2/20 | 0.36 |
| ▸ | SPHK1 | Q9NYA1 | 6/20 | 0.36 |
| ▸ | SPHK2 | Q9NRA0 | 5/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25686622 | 0.94 | CHRM5 (0.48) | GBA1CHRM5ADRA2CPOLBL3MBTL1 | |
| SCHEMBL8587272 | 0.94 | POLB (0.45) | GBA1POLBL3MBTL1JAK2JAK1 | |
| SCHEMBL19616665 | 0.94 | POLB (0.45) | GBA1POLBL3MBTL1JAK2JAK1 | |
| SCHEMBL14045602 | 0.94 | POLB (0.45) | GBA1POLBL3MBTL1JAK2JAK1 | |
| SCHEMBL25686459 | 0.91 | GBA1 (0.39) | GBA1CHRM5ADRA2CPOLBL3MBTL1 | |
| SCHEMBL25686656 | 0.89 | GBA1 (0.38) | GBA1CHRM5ADRA2CPOLBL3MBTL1 | |
| SCHEMBL25686542 | 0.88 | GBA1 (0.37) | GBA1CHRM5ADRA2CPOLBL3MBTL1 | |
| SCHEMBL25686547 | 0.88 | GBA1 (0.37) | GBA1CHRM5ADRA2CPOLBL3MBTL1 | |
| SCHEMBL25686524 | 0.87 | GBA1 (0.36) | GBA1L3MBTL1JAK2JAK1TYK2 | |
| SCHEMBL25686606 | 0.87 | GBA1 (0.40) | GBA1JAK2JAK1TYK2CFB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0490962-A4 | ANTIPSYCHOTIC 1-CYCLOALKYLPIPERIDINES | — | 1993-03-03 | — | — | EP | disclosed |