Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | JAK1 | P23458 | 2/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | GBA1 | P04062 | 3/20 | 0.42 |
| ▸ | SPHK1 | Q9NYA1 | 9/20 | 0.40 |
| ▸ | SPHK2 | Q9NRA0 | 8/20 | 0.40 |
| ▸ | MELK | Q14680 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14045602 | 1.00 | POLB (0.45) | POLBL3MBTL1JAK2JAK1TYK2 | |
| SCHEMBL19616665 | 1.00 | POLB (0.45) | POLBL3MBTL1JAK2JAK1TYK2 | |
| SCHEMBL9521804 | 0.94 | GBA1 (0.44) | POLBL3MBTL1JAK2JAK1TYK2 | |
| SCHEMBL31193306 | 0.88 | GBA1 (0.50) | POLBL3MBTL1JAK2JAK1TYK2 | |
| SCHEMBL25686622 | 0.88 | CHRM5 (0.48) | POLBL3MBTL1JAK2JAK1TYK2 | |
| SCHEMBL25686459 | 0.85 | GBA1 (0.39) | POLBL3MBTL1JAK2JAK1TYK2 | |
| SCHEMBL25686656 | 0.84 | GBA1 (0.38) | POLBL3MBTL1JAK2JAK1TYK2 | |
| SCHEMBL10843295 | 0.83 | SIGMAR1 (0.38) | POLBL3MBTL1JAK2JAK1TYK2 | |
| SCHEMBL25686547 | 0.82 | GBA1 (0.37) | POLBL3MBTL1JAK2JAK1TYK2 | |
| SCHEMBL25686542 | 0.82 | GBA1 (0.37) | POLBL3MBTL1JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998039295-A1 | (R)N-(1-CYCLOPROPYLMETHYLPYRROLIDIN-2-YLMETHYL)BENZAMIDE AND ITS USE AS AN ANTIDIARRHOEAL | JOUVEINAL (FR) | 1998-09-11 | — | — | WO | disclosed |