SCHEMBL9523231

SCHEMBL9523231

CCOC(=O)c1cc(-n2c(=O)cc3n(c2=O)CCC3)c(F)cc1Cl

nearest known ligand 0.42

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PDE3B Q13370 8/20 0.42
PDE3A Q14432 8/20 0.42
BAZ2B Q9UIF8 1/20 0.41
BAZ2A Q9UIF9 1/20 0.41
HPGD P15428 3/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
LMNA P02545 1/20 0.36
MAPT P10636 1/20 0.36
PPOX P50336 2/20 0.36
CMA1 P23946 1/20 0.36
KDM4E B2RXH2 3/20 0.35
ALDH1A1 P00352 2/20 0.35
HSD17B10 Q99714 2/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2C19 P33261 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10987128 0.82 BAZ2B (0.46) PDE3BPDE3ABAZ2BBAZ2AHPGD
SCHEMBL7015806 0.78 HSP90AA1 (0.33) HPGD
SCHEMBL9723119 0.78 PDE3B (0.42) PDE3BPDE3ABAZ2BBAZ2AHPGD
SCHEMBL6336900 0.76 BAZ2B (0.46) BAZ2BBAZ2AHPGDSMN1; SMN2LMNA
SCHEMBL9664791 0.75 DHODH (0.51)
SCHEMBL7020918 0.75 PPOX (0.50) HPGDMAPTPPOXKDM4EALDH1A1
SCHEMBL25285902 0.73 BAZ2B (0.47) BAZ2BBAZ2AHPGDSMN1; SMN2LMNA
SCHEMBL10647226 0.73 KDM4E (0.43) PDE3BPDE3ABAZ2BBAZ2AHPGD
SCHEMBL9706599 0.73 BAZ2B (0.44) BAZ2BBAZ2AHPGDSMN1; SMN2LMNA
SCHEMBL10531901 0.71 BAZ2B (0.43) BAZ2BBAZ2AHPGDSMN1; SMN2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-5025173-A None JP disclosed
JP-H0525173-A CONDENSED PYRIMIDINEDIONE DERIVATIVE AND HERBICIDE NISSAN CHEM IND LTD 1993-02-02 JP disclosed