Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
| ▸ | PRKACA | P17612 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18884401 | 0.73 | ALDH1A1 (0.38) | ALDH1A1CA2 | |
| SCHEMBL19382255 | 0.65 | ALDH1A1 (0.41) | TSHRALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL15902708 | 0.62 | CYP2C19 (0.35) | TSHRALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL22063724 | 0.62 | MECP2 (0.36) | TSHRALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL19036527 | 0.62 | ALDH1A1 (0.39) | TSHRALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6844725 | 0.62 | TNKS2 (0.45) | TSHRALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL132148 | 0.62 | TSHR (0.36) | TSHRCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL19452810 | 0.61 | ALDH1A1 (0.42) | TSHRALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL22506864 | 0.58 | CYP2C19 (0.39) | TSHRALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL31041077 | 0.55 | HDAC4 (0.46) | TSHRCYP1A2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0569457-A1 | USE OF THIAZOLO- 2,3-A]ISOINDOLE DERIVATIVES AS ANTIVIRAL MEDICAMENTS AND NOVEL THIAZOLO- 2,3-A]ISOINDOLE DERIVATIVES. | BOEHRINGER MANNHEIM GMBH (DE) | 1993-11-18 | — | — | EP | disclosed |