Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CDC25B | P30305 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9523650 | 0.94 | TSHR (0.47) | TSHRALDH1A1TDP1MAPTL3MBTL1 | |
| SCHEMBL2525946 | 0.85 | TSHR (0.51) | TSHRALDH1A1TDP1L3MBTL1PKM | |
| SCHEMBL19413591 | 0.83 | TSHR (0.49) | TSHRALDH1A1TDP1MAPTL3MBTL1 | |
| SCHEMBL27317724 | 0.83 | TSHR (0.49) | TSHRALDH1A1TDP1L3MBTL1PKM | |
| SCHEMBL27924284 | 0.83 | TSHR (0.49) | TSHRALDH1A1TDP1MAPTL3MBTL1 | |
| SCHEMBL27900404 | 0.83 | TSHR (0.49) | TSHRALDH1A1TDP1MAPTL3MBTL1 | |
| SCHEMBL28171839 | 0.83 | TSHR (0.49) | TSHRALDH1A1TDP1MAPTL3MBTL1 | |
| SCHEMBL9522868 | 0.82 | KMT2A (0.53) | TSHRALDH1A1MAPTKDM4EGAA | |
| SCHEMBL27771692 | 0.79 | TSHR (0.58) | TSHRALDH1A1TDP1MAPTL3MBTL1 | |
| SCHEMBL20746225 | 0.78 | TSHR (0.51) | TSHRALDH1A1TDP1L3MBTL1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0523067-A1 | CROP-SELECTIVE HERBICIDAL SULFONAMIDES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1993-01-20 | — | — | EP | disclosed |