Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9522803 | 0.91 | TP53 (0.39) | TP53THRBMAPTRAB9AL3MBTL1 | |
| SCHEMBL9834217 | 0.88 | TP53 (0.43) | TP53THRBMAPTPTGS1PTGS2 | |
| SCHEMBL9170542 | 0.86 | CCNA2 (0.34) | — | |
| SCHEMBL9832793 | 0.85 | TP53 (0.46) | TP53THRBMAPTPTGS1PTGS2 | |
| SCHEMBL9522928 | 0.84 | TP53 (0.42) | TP53THRBMAPTPTGS1PTGS2 | |
| SCHEMBL8113736 | 0.84 | TP53 (0.45) | TP53THRBMAPTPTGS1PTGS2 | |
| SCHEMBL9339764 | 0.84 | TP53 (0.45) | TP53THRBMAPTPTGS1PTGS2 | |
| SCHEMBL9316737 | 0.81 | TP53 (0.49) | TP53THRBMAPTPTGS1PTGS2 | |
| SCHEMBL8111901 | 0.80 | TP53 (0.42) | TP53THRBMAPTPTGS1PTGS2 | |
| SCHEMBL9834310 | 0.79 | TP53 (0.46) | TP53THRBMAPTRAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0420883-B1 | TRICYCLIC 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | ERBA CARLO SPA (IT) | 1993-11-03 | — | — | EP | disclosed |
| US-5166152-A | Immunostimulants, bactericides, viricides, antitumor agents | FARMITALIA CARLO ERBA S.R.L. (IT) | 1992-11-24 | — | — | US | disclosed |
| EP-0420883-A1 | TRICYCLIC 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION. | ERBA CARLO SPA (IT) | 1991-04-10 | — | — | EP | disclosed |
| WO-1989012638-A1 | TRICYCLIC 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-12-28 | — | — | WO | disclosed |