Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.82 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | FNTA | P49354 | 4/20 | 0.52 |
| ▸ | FNTB | P49356 | 4/20 | 0.52 |
| ▸ | PGGT1B | P53609 | 4/20 | 0.52 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL77675 | 0.81 | ALDH1A1 (0.64) | ALDH1A1LMNASMN1; SMN2CYP19A1CYP11B1 | |
| SCHEMBL76730 | 0.81 | ALDH1A1 (0.64) | ALDH1A1LMNASMN1; SMN2CYP19A1CYP11B1 | |
| SCHEMBL10581105 | 0.80 | ALDH1A1 (0.63) | ALDH1A1LMNASMN1; SMN2CYP19A1CYP11B1 | |
| SCHEMBL9527373 | 0.78 | ALDH1A1 (0.67) | ALDH1A1LMNASMN1; SMN2CYP19A1CYP11B1 | |
| SCHEMBL9523331 | 0.78 | ALDH1A1 (0.67) | ALDH1A1LMNASMN1; SMN2CYP19A1CYP11B1 | |
| SCHEMBL10942842 | 0.78 | ALDH1A1 (0.65) | ALDH1A1CYP19A1FNTAFNTBPGGT1B | |
| SCHEMBL10579958 | 0.78 | ALDH1A1 (0.67) | ALDH1A1LMNASMN1; SMN2CYP19A1CYP11B1 | |
| SCHEMBL521141 | 0.77 | ALDH1A1 (0.59) | ALDH1A1LMNASMN1; SMN2PKM | |
| SCHEMBL10582682 | 0.76 | CYP19A1 (0.59) | ALDH1A1LMNASMN1; SMN2CYP19A1CYP11B1 | |
| SCHEMBL11009648 | 0.76 | ALDH1A1 (0.60) | ALDH1A1CYP19A1FNTAFNTBPGGT1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0293978-B1 | (1H-AZOL-1-YLMETHYL)SUBSTITUTED BENZOTRIAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-09-15 | — | — | EP | disclosed |
| US-5039677-A | Estrogen inhibitor | JANSSEN PHARMACEUTICA N.V. (CA) | 1991-08-13 | — | — | US | disclosed |
| US-4943574-A | AROMATASE INHIBITORS, ESTROGEN DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-07-24 | — | — | US | disclosed |
| EP-0293978-A2 | (1H-azol-1-ylmethyl)substituted benzotriazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-12-07 | — | — | EP | disclosed |