Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 14/20 | 0.44 |
| ▸ | PIK3R2 | O00459 | 14/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 14/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 14/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 14/20 | 0.44 |
| ▸ | PIK3R5 | Q8WYR1 | 14/20 | 0.44 |
| ▸ | PIK3R3 | Q92569 | 14/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9316016 | 0.94 | PIK3CD (0.48) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL9523867 | 0.90 | PIK3CD (0.47) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL9833530 | 0.88 | RIPK1 (0.41) | SMN1; SMN2KDM4ENPC1MAPTTSHR | |
| SCHEMBL9523411 | 0.87 | PIK3CD (0.48) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL9832438 | 0.86 | MAPT (0.45) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL9834162 | 0.84 | CCNA2 (0.40) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL9831070 | 0.84 | NR1H4 (0.41) | MAPTTSHRALDH1A1HIF1A | |
| SCHEMBL9831823 | 0.84 | MAPT (0.46) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL9835144 | 0.83 | PIK3CD (0.46) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL9178148 | 0.83 | PIK3CD (0.49) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0420883-B1 | TRICYCLIC 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | ERBA CARLO SPA (IT) | 1993-11-03 | — | — | EP | disclosed |
| US-5166152-A | Immunostimulants, bactericides, viricides, antitumor agents | FARMITALIA CARLO ERBA S.R.L. (IT) | 1992-11-24 | — | — | US | disclosed |
| EP-0420883-A1 | TRICYCLIC 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION. | ERBA CARLO SPA (IT) | 1991-04-10 | — | — | EP | disclosed |
| WO-1989012638-A1 | TRICYCLIC 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-12-28 | — | — | WO | disclosed |