Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 2/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.52 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | CSF1R | P07333 | 1/20 | 0.52 |
| ▸ | PRKACA | P17612 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.52 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.52 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.52 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | LTK | P29376 | 1/20 | 0.37 |
| ▸ | GRK5 | P34947 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL260187 | 0.98 | CDK8 (0.53) | CDK8ROCK1CHEK1DYRK1BMAP4K4 | |
| Hydrochloric Acid SCHEMBL7834151 | 0.96 | CDK8 (0.52) | CDK8ROCK1CHEK1DYRK1BMAP4K4 | |
| Bromide SCHEMBL2265015 | 0.75 | CDK8 (0.52) | CDK8ROCK1CHEK1DYRK1BMAP4K4 | |
| Bromide SCHEMBL9692647 | 0.75 | CDK8 (0.52) | CDK8ROCK1CHEK1DYRK1BMAP4K4 | |
| SCHEMBL4770221 | 0.72 | CDK8 (0.53) | CDK8ROCK1CHEK1DYRK1BMAP4K4 | |
| SCHEMBL18324191 | 0.72 | CDK8 (0.53) | CDK8ROCK1CHEK1DYRK1BMAP4K4 | |
| SCHEMBL260258 | 0.72 | CDK8 (0.56) | CDK8ROCK1CHEK1DYRK1BMAP4K4 | |
| SCHEMBL22836801 | 0.72 | CDK8 (0.53) | CDK8ROCK1CHEK1DYRK1BMAP4K4 | |
| SCHEMBL334306 | 0.72 | CDK8 (0.53) | CDK8ROCK1CHEK1DYRK1BMAP4K4 | |
| SCHEMBL7896883 | 0.72 | CDK8 (0.58) | CDK8ROCK1CHEK1DYRK1BMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0249170-B1 | CEPHEM COMPOUNDS, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1993-03-17 | — | — | EP | disclosed |
| US-4921851-A | Cephem compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1990-05-01 | — | — | US | disclosed |
| EP-0249170-A2 | Cephem compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1987-12-16 | — | — | EP | disclosed |