SCHEMBL9524459

SCHEMBL9524459

COC(OC)C(CCCc1ccc(C(=O)OC(C)(C)C)cc1)CC(C#N)C#N

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP4A11 Q02928 3/20 0.38
CYP4F2 P78329 2/20 0.37
CTSS P25774 1/20 0.33
CTSK P43235 1/20 0.33
SIRT2 Q8IXJ6 1/20 0.33
SIRT1 Q96EB6 1/20 0.33
CA12 O43570 1/20 0.33
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
CA9 Q16790 1/20 0.33
CA14 Q9ULX7 1/20 0.33
MMP2 P08253 1/20 0.32
MMP3 P08254 1/20 0.32
SLC7A5 Q01650 1/20 0.32
ELANE P08246 1/20 0.31
SMO Q99835 1/20 0.31
PPARA Q07869 1/20 0.30
PPARG P37231 1/20 0.30
GABRA1 P14867 1/20 0.30
GABRG2 P18507 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9088289 0.84 CYP4A11 (0.41) CYP4A11CYP4F2CTSSCTSKSIRT2
SCHEMBL9446097 0.84 CYP4A11 (0.46) CYP4A11CYP4F2SIRT2SIRT1CA12
SCHEMBL9086571 0.81 CYP4A11 (0.42) CYP4A11CYP4F2CTSSCTSKSIRT2
SCHEMBL9524969 0.80 CYP4A11 (0.38) CYP4A11CYP4F2SIRT2SIRT1CA12
SCHEMBL9085713 0.79 CA12 (0.39) CYP4A11CYP4F2CTSSCTSKSIRT2
SCHEMBL9446045 0.78 CYP4A11 (0.42) CYP4A11CYP4F2CTSKSIRT2SIRT1
SCHEMBL8997190 0.76 CYP4A11 (0.43) CYP4A11CYP4F2CTSSCTSKSIRT2
SCHEMBL9446036 0.76 CYP4A11 (0.45) CYP4A11CYP4F2SIRT2SIRT1CA12
SCHEMBL9446068 0.76 CYP4A11 (0.42) CYP4A11CYP4F2SIRT2SIRT1CA12
SCHEMBL8568070 0.73 CYP4A11 (0.45) CYP4A11CYP4F2SIRT2SIRT1CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0340905-B1 Fused pyrimidines, their production and use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1993-12-08 EP disclosed
US-4946846-A ANTITUMOR AGENTS; NONTOXIC TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1990-08-07 US disclosed