SCHEMBL8997190

SCHEMBL8997190

COC(=O)C(CCCc1ccc(C(=O)OC(C)(C)C)cc1)C(C#N)C#N

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP4A11 Q02928 3/20 0.43
CYP4F2 P78329 2/20 0.42
CTSS P25774 2/20 0.37
CTSK P43235 2/20 0.37
HDAC1 Q13547 1/20 0.35
HDAC6 Q9UBN7 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
MMP3 P08254 2/20 0.35
MMP1 P03956 1/20 0.35
MMP9 P14780 1/20 0.35
CA12 O43570 1/20 0.34
CA1 P00915 1/20 0.34
CA2 P00918 1/20 0.34
CA9 Q16790 1/20 0.34
CA14 Q9ULX7 1/20 0.34
SIRT2 Q8IXJ6 1/20 0.34
SIRT1 Q96EB6 1/20 0.34
LOXL2 Q9Y4K0 1/20 0.34
RAPGEF3 O95398 1/20 0.34
HRH1 P35367 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9446036 0.86 CYP4A11 (0.45) CYP4A11CYP4F2HDAC1HDAC6L3MBTL1
SCHEMBL9088289 0.82 CYP4A11 (0.41) CYP4A11CYP4F2CTSSCTSKHDAC1
SCHEMBL8997380 0.81 CYP4A11 (0.47) CYP4A11CYP4F2HDAC1HDAC6L3MBTL1
SCHEMBL9086571 0.79 CYP4A11 (0.42) CYP4A11CYP4F2CTSSCTSKHDAC1
SCHEMBL9085713 0.77 CA12 (0.39) CYP4A11CYP4F2CTSSCTSKHDAC1
SCHEMBL9524459 0.76 CYP4A11 (0.38) CYP4A11CYP4F2CTSSCTSKHDAC1
SCHEMBL8568070 0.76 CYP4A11 (0.45) CYP4A11CYP4F2MMP3MMP1MMP9
SCHEMBL8982437 0.73 CYP4A11 (0.54) CYP4A11CYP4F2MMP3CA12CA1
SCHEMBL7855043 0.72 CYP4A11 (0.68) CYP4A11CYP4F2CA12CA1CA2
SCHEMBL9446097 0.72 CYP4A11 (0.46) CYP4A11CYP4F2HDAC1HDAC6MMP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0334636-B1 Pyrrolopyrimidine derivatives, their production and use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1996-10-23 EP disclosed
US-5539113-A ANTITUMOR AGENTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-07-23 US disclosed
US-5296600-A Antitumor agents TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1994-03-22 US disclosed
US-5106974-A Antitumor and -carcinogenic agents TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1992-04-21 US disclosed
US-4997838-A Antitumor agents TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1991-03-05 US disclosed
EP-0334636-A2 Pyrrolopyrimidine derivatives, their production and use Takeda Chemical Industries, Ltd. (JP) 1989-09-27 EP disclosed