Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | COMT | P21964 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9525950 | 0.81 | KMT2A (0.45) | KMT2AMAPTHSD17B10TSHRCOMT | |
| SCHEMBL9827011 | 0.79 | KMT2A (0.44) | KMT2AMAPTHSD17B10TSHRCOMT | |
| SCHEMBL9367269 | 0.79 | MAPT (0.44) | KMT2AMAPTHSD17B10TSHRKDM4E | |
| SCHEMBL9526037 | 0.78 | KMT2A (0.42) | KMT2AMAPTHSD17B10TSHRCOMT | |
| SCHEMBL1086028 | 0.75 | KMT2A (0.56) | KMT2AMAPTHSD17B10TSHRCOMT | |
| SCHEMBL1720659 | 0.73 | KMT2A (0.54) | KMT2AMAPTHSD17B10TSHRCOMT | |
| SCHEMBL20892464 | 0.71 | MAPT (0.47) | KMT2AMAPTHSD17B10TSHRKDM4E | |
| SCHEMBL1529858 | 0.69 | MAPT (0.50) | KMT2AMAPTHSD17B10TSHRCOMT | |
| SCHEMBL1086031 | 0.68 | MAPT (0.48) | KMT2AMAPTHSD17B10TSHRKDM4E | |
| SCHEMBL9826167 | 0.68 | MAPT (0.48) | KMT2AMAPTHSD17B10TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1025027-C | Organic compounds and their use as pharmaceuticals | LILLY SA (ES) | 1994-06-15 | — | — | CN | disclosed |
| EP-0297697-B1 | Thiophene-2-carboxamide derivatives and their pharmaceutical use | LILLY SA (ES) | 1993-12-29 | — | — | EP | disclosed |
| US-4904686-A | 3-ALKOXYTHIOPHENE-2-CARBOXAMIDES; CENTRAL NERVOUS SYSTEM DISORDERS | LILLY INDUSTRIES LIMITED (GB) | 1990-02-27 | — | — | US | disclosed |
| CN-1030916-A | Organic compound and as the application of medicine | LILLY SA (ES) | 1989-02-08 | — | — | CN | disclosed |
| EP-0297697-A1 | Thiophene-2-carboxamide derivatives and their pharmaceutical use | LILLY S.A. (ES) | 1989-01-04 | — | — | EP | disclosed |