Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.53 |
| ▸ | MEN1 | O00255 | 7/20 | 0.53 |
| ▸ | HTT | P42858 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.48 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.47 |
| ▸ | CASR | P41180 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | THRA | P10827 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10911763 | 0.98 | MAPT (0.52) | MAPTALDH1A1KMT2AMEN1HTT | |
| SCHEMBL11207225 | 0.95 | MAPT (0.50) | MAPTALDH1A1KMT2AMEN1HTT | |
| SCHEMBL10911757 | 0.86 | MAPT (0.53) | MAPTALDH1A1KMT2AMEN1HTT | |
| SCHEMBL27979454 | 0.85 | MAPT (0.55) | MAPTALDH1A1KMT2AMEN1HTT | |
| Hydrochloric Acid SCHEMBL30605752 | 0.82 | MEN1 (0.56) | MAPTALDH1A1KMT2AMEN1HTT | |
| SCHEMBL157003 | 0.82 | MEN1 (0.56) | MAPTALDH1A1KMT2AMEN1HTT | |
| SCHEMBL30421886 | 0.82 | MEN1 (0.56) | MAPTALDH1A1KMT2AMEN1HTT | |
| Hydrochloric Acid SCHEMBL28590040 | 0.82 | MEN1 (0.56) | MAPTALDH1A1KMT2AMEN1HTT | |
| SCHEMBL9514351 | 0.82 | FABP4 (0.50) | MAPTALDH1A1KMT2AMEN1HTT | |
| SCHEMBL11527837 | 0.81 | MAPT (0.56) | MAPTALDH1A1KMT2AMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4585867-A | Process for the preparation of 4-quinolinones | RHONE-POULENC SANTE (FR) | 1986-04-29 | — | — | US | claimed |
| EP-0056763-B1 | PROCESS FOR THE PREPARATION OF 4-QUINOLINONES | RHONE-POULENC SANTE (FR) | 1984-07-04 | — | — | EP | claimed |
| EP-0056764-B1 | PROCESS FOR THE PREPARATION OF 7-CHLORO-1,2,3,4-TETRAHYDRO-4-QUINOLONE | RHONE-POULENC SANTE (FR) | 1983-12-28 | — | — | EP | claimed |
| US-4421918-A | Process for the preparation of 7-chloro-1,2,3,4-tetrahydroquinolin-4-one | RHONE-POULENC SANTE (FR) | 1983-12-20 | — | — | US | claimed |
| US-4412075-A | Process for the preparation of quinolin-4-ones | RHONE-POULENC SANTE (FR) | 1983-10-25 | — | — | US | claimed |
| JP-4112860-A | — | — | None | — | — | JP | disclosed |
| EP-0301751-B1 | PYRIDINIUM DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1993-03-10 | — | — | EP | disclosed |
| JP-H04112860-A | N-(SUBSTITUTED BENZOYL)-N-(3-CHLOROPHENYL)-BETA-ALANINE AND SALT THEREOF | HODOGAYA CHEM CO LTD | 1992-04-14 | — | — | JP | disclosed |
| US-4962113-A | PLATELET ACTIVATING FACTOR ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD (JP) | 1990-10-09 | — | — | US | disclosed |
| EP-0301751-A1 | Pyridinium derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1989-02-01 | — | — | EP | disclosed |
| US-4593101-A | Process for the preparation of 4-quinolinones | RHONE-POULENC SANTE (FR) | 1986-06-03 | — | — | US | disclosed |
| US-4585867-A | Process for the preparation of 4-quinolinones | RHONE-POULENC SANTE (FR) | 1986-04-29 | — | — | US | disclosed |
| US-4508902-A | OXIDATION OF 1,2,3,4-TETRAHYDROQUINOLINE-4-ONES | RHONE-POULENC SANTE (FR) | 1985-04-02 | — | — | US | disclosed |
| US-4421920-A | AMINATION, AROMATIZATION, RUTHENIUM CATALYST | RHONE-POULENC SANTE (FR) | 1983-12-20 | — | — | US | disclosed |
| US-4421918-A | Process for the preparation of 7-chloro-1,2,3,4-tetrahydroquinolin-4-one | RHONE-POULENC SANTE (FR) | 1983-12-20 | — | — | US | disclosed |
| US-4421918-A | Process for the preparation of 7-chloro-1,2,3,4-tetrahydroquinolin-4-one | RHONE-POULENC SANTE (FR) | 1983-12-20 | — | — | US | disclosed |
| US-4412076-A | Preparation of 4-hydroxyquinolines | RHONE-POULENC SANTE (FR) | 1983-10-25 | — | — | US | disclosed |
| US-4412075-A | Process for the preparation of quinolin-4-ones | RHONE-POULENC SANTE (FR) | 1983-10-25 | — | — | US | disclosed |