Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 9/20 | 0.52 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9078558 | 0.82 | CYP19A1 (0.60) | CYP17A1CYP26A1CYP11B1CYP11B2CYP19A1 | |
| Hydrochloric Acid SCHEMBL9663513 | 0.77 | CYP17A1 (0.51) | CYP17A1CYP26A1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL27274843 | 0.77 | CYP17A1 (0.51) | CYP17A1CYP26A1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL19054891 | 0.77 | CYP17A1 (0.54) | CYP17A1CYP26A1CYP11B1CYP11B2CYP19A1 | |
| Hydrochloric Acid SCHEMBL9664030 | 0.76 | CYP17A1 (0.53) | CYP17A1CYP26A1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL242516 | 0.75 | EIF4A3 (0.39) | — | |
| SCHEMBL9662820 | 0.73 | CYP17A1 (0.52) | CYP17A1CYP26A1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL9662043 | 0.73 | CYP17A1 (0.50) | CYP17A1CYP26A1CYP11B1CYP11B2 | |
| SCHEMBL11659128 | 0.72 | — | — | |
| SCHEMBL21104304 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0293978-B1 | (1H-AZOL-1-YLMETHYL)SUBSTITUTED BENZOTRIAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-09-15 | — | — | EP | disclosed |
| US-5039677-A | Estrogen inhibitor | JANSSEN PHARMACEUTICA N.V. (CA) | 1991-08-13 | — | — | US | disclosed |
| US-4943574-A | AROMATASE INHIBITORS, ESTROGEN DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-07-24 | — | — | US | disclosed |