Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | G6PD | P11413 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MPI | P34949 | 1/20 | 0.41 |
| ▸ | EP300 | Q09472 | 1/20 | 0.41 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.41 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 2/20 | 0.39 |
| ▸ | CASP6 | P55212 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27693209 | 0.81 | HSD17B10 (0.39) | HPGDHSD17B10TDP1L3MBTL1POLB | |
| SCHEMBL2340654 | 0.73 | HPGD (0.57) | HPGDTDP1POLBGAAALDH1A1 | |
| SCHEMBL29150182 | 0.71 | TDP1 (0.53) | HPGDHSD17B10TDP1L3MBTL1POLB | |
| SCHEMBL693321 | 0.71 | SLC11A2 (0.38) | HSD17B10TDP1L3MBTL1GAAALDH1A1 | |
| SCHEMBL28199867 | 0.71 | HSD17B10 (0.56) | HSD17B10TDP1L3MBTL1POLBAPEX1 | |
| SCHEMBL30486192 | 0.70 | HSD17B10 (0.73) | HSD17B10TDP1L3MBTL1POLBAPEX1 | |
| SCHEMBL29204149 | 0.70 | HSD17B10 (0.73) | HSD17B10TDP1L3MBTL1POLBAPEX1 | |
| SCHEMBL9959877 | 0.70 | HPGD (0.57) | HPGDTDP1GAAMAPTPKM | |
| SCHEMBL1459655 | 0.70 | HPGD (0.53) | HPGDTDP1GAAALDH1A1MAPT | |
| SCHEMBL27481595 | 0.70 | HPGD (0.53) | HPGDTDP1L3MBTL1POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0378358-B1 | Anti-inflammmatory 1-heteroaryl-3-acyl-2-oxindoles | PFIZER (US) | 1993-11-03 | — | — | EP | disclosed |
| US-5116854-A | Enzyme inhibitors | PFIZER INC. (US) | 1992-05-26 | — | — | US | disclosed |
| WO-1990008145-A1 | ANTI-INFLAMMATORY 1-HETEROARYL-3-ACYL-2-OXINDOLES | PFIZER INC. (US) | 1990-07-26 | — | — | WO | disclosed |
| EP-0378358-A1 | Anti-inflammmatory 1-heteroaryl-3-acyl-2-oxindoles | PFIZER INC. (US) | 1990-07-18 | — | — | EP | disclosed |