SCHEMBL9525920

SCHEMBL9525920

CC(CO)(CO)NCc1ccc2oc3ccccc3c2c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.47
CYP2C19 P33261 2/20 0.47
CYP2D6 P10635 1/20 0.47
LMNA P02545 4/20 0.41
ALDH1A1 P00352 4/20 0.41
MAPT P10636 4/20 0.41
SMN1; SMN2 Q16637 4/20 0.41
KDM4E B2RXH2 3/20 0.41
HPGD P15428 3/20 0.41
NPC1 O15118 3/20 0.41
RAB9A P51151 3/20 0.41
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
PDE10A Q9Y233 4/20 0.39
PTGER4 P35408 1/20 0.39
TDP1 Q9NUW8 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
CYP2C9 P11712 1/20 0.38
POLB P06746 1/20 0.38
AHR P35869 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL9526903 0.99 CYP1A2 (0.46) CYP1A2CYP2C19CYP2D6LMNAALDH1A1
SCHEMBL9779193 0.86 KDM4E (0.40) CYP1A2CYP2C19CYP2D6ALDH1A1MAPT
SCHEMBL10928176 0.82 SLC2A1 (0.37) CYP1A2CYP2C19CYP2D6LMNAALDH1A1
SCHEMBL10682965 0.82 SLC2A1 (0.40) CYP1A2CYP2D6ALDH1A1RAB9AMEN1
SCHEMBL9778848 0.81 SLC2A1 (0.48) ALDH1A1MAPTKDM4EHPGDNPC1
Hydrochloric Acid SCHEMBL10679660 0.81 HTT (0.41) CYP1A2CYP2D6LMNAALDH1A1RAB9A
Hydrochloric Acid SCHEMBL10986411 0.81 HTT (0.41) CYP1A2CYP2D6LMNAALDH1A1RAB9A
SCHEMBL9754594 0.80 HTR1B (0.35) CYP2D6ALDH1A1
SCHEMBL9843700 0.79 ALDH1A1 (0.33) CYP2D6ALDH1A1MEN1KMT2A
Hydrochloric Acid SCHEMBL9754578 0.79 HTR1B (0.34) CYP2D6ALDH1A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5049581-A Dibenzofurans having anti-tumor activity BURROUGHS WELLCOME CO. (US) 1991-09-17 US claimed
EP-0183439-A2 Polycyclic compounds, their preparation and use and formulations containing them THE WELLCOME FOUNDATION LIMITED (GB) 1986-06-04 EP claimed
EP-0183439-B1 POLYCYCLIC COMPOUNDS, THEIR PREPARATION AND USE AND FORMULATIONS CONTAINING THEM THE WELLCOME FOUNDATION LIMITED (GB) 1993-02-03 EP disclosed
US-5049581-A Dibenzofurans having anti-tumor activity BURROUGHS WELLCOME CO. (US) 1991-09-17 US disclosed
US-5017600-A Antitumor BURROUGHS WELLCOME CO. (US) 1991-05-21 US disclosed
US-5008286-A Antitumor agents BURROUGHS WELLCOME CO. (US) 1991-04-16 US disclosed
US-4970227-A ANTITUMOR BURROUGHS WELLCOME CO. (US) 1990-11-13 US disclosed
US-4965285-A ANTITUMOR AGENTS BURROUGHS WELLCOME CO. (US) 1990-10-23 US disclosed
US-4866070-A ANTITUMOR AGENT BURROUGHS WELLCOME CO. (US) 1989-09-12 US disclosed