Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 9/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PRNP | P04156 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9781555 | 0.77 | MRE11 (0.52) | DHODHMEN1KMT2AGAAKDM4E | |
| SCHEMBL9525592 | 0.77 | MRE11 (0.52) | DHODHMEN1KMT2AGAAKDM4E | |
| SCHEMBL9812376 | 0.75 | DHODH (0.78) | DHODHNPC1RAB9AMEN1KMT2A | |
| SCHEMBL9812374 | 0.75 | DHODH (0.78) | DHODHNPC1RAB9AMEN1KMT2A | |
| SCHEMBL9529028 | 0.71 | DHODH (0.50) | DHODHMEN1KMT2AGAAPOLB | |
| SCHEMBL9525750 | 0.71 | DHODH (0.50) | DHODHMEN1KMT2AGAAPOLB | |
| SCHEMBL9529031 | 0.71 | DHODH (0.50) | DHODHMEN1KMT2AGAAPOLB | |
| SCHEMBL9526472 | 0.70 | DHODH (0.51) | DHODHMEN1KMT2AGAAPOLB | |
| SCHEMBL9528683 | 0.70 | DHODH (0.49) | DHODHMEN1KMT2AGAAKDM4E | |
| SCHEMBL9526469 | 0.70 | DHODH (0.51) | DHODHMEN1KMT2AGAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0259972-B1 | HETEROCYCLIC PROPENE AMIDE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | LILLY INDUSTRIES LIMITED (GB) | 1993-07-14 | — | — | EP | disclosed |
| US-4983619-A | Leukotriene antagonists | LILLY INDUSTRIES LIMITED (GB) | 1991-01-08 | — | — | US | disclosed |
| EP-0259972-A2 | Heterocyclic propene amide derivatives, processes for their preparation and their use as pharmaceuticals | LILLY INDUSTRIES LIMITED (GB) | 1988-03-16 | — | — | EP | disclosed |