Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 12/20 | 0.49 |
| ▸ | PGR | P06401 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9812374 | 0.76 | DHODH (0.78) | DHODHMEN1ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL9812376 | 0.76 | DHODH (0.78) | DHODHMEN1ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL9529031 | 0.72 | DHODH (0.50) | DHODHMEN1ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL9529028 | 0.72 | DHODH (0.50) | DHODHMEN1ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL9525750 | 0.72 | DHODH (0.50) | DHODHMEN1ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL9526469 | 0.71 | DHODH (0.51) | DHODHMEN1ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL9526472 | 0.71 | DHODH (0.51) | DHODHMEN1ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL9526022 | 0.70 | DHODH (0.47) | DHODHMEN1ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL9525592 | 0.70 | MRE11 (0.52) | DHODHMEN1ALDH1A1KMT2AGAA | |
| SCHEMBL9781555 | 0.70 | MRE11 (0.52) | DHODHMEN1ALDH1A1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0259972-B1 | HETEROCYCLIC PROPENE AMIDE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | LILLY INDUSTRIES LIMITED (GB) | 1993-07-14 | — | — | EP | disclosed |
| US-4983619-A | Leukotriene antagonists | LILLY INDUSTRIES LIMITED (GB) | 1991-01-08 | — | — | US | disclosed |
| EP-0259972-A2 | Heterocyclic propene amide derivatives, processes for their preparation and their use as pharmaceuticals | LILLY INDUSTRIES LIMITED (GB) | 1988-03-16 | — | — | EP | disclosed |