Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | VHL | P40337 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.34 |
| ▸ | CHRNA5 | P30532 | 2/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4975148 | 0.75 | HCAR2 (0.47) | HCAR2ALDH1A1SMN1; SMN2POLBVHL | |
| SCHEMBL3723489 | 0.75 | HCAR2 (0.52) | HCAR2ALDH1A1SMN1; SMN2POLBVHL | |
| SCHEMBL15881089 | 0.74 | HCAR2 (0.46) | HCAR2ALDH1A1SMN1; SMN2POLBVHL | |
| SCHEMBL27924807 | 0.71 | HCAR2 (0.43) | HCAR2ALDH1A1SMN1; SMN2POLBVHL | |
| SCHEMBL23370836 | 0.69 | HCAR2 (0.53) | HCAR2ALDH1A1SMN1; SMN2POLBSYK | |
| SCHEMBL11145569 | 0.68 | TSHR (0.35) | ALDH1A1SMN1; SMN2POLBLMNATSHR | |
| SCHEMBL28030170 | 0.67 | ALDH1A1 (0.41) | ALDH1A1KMT2AMEN1LMNATSHR | |
| SCHEMBL9205678 | 0.66 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2POLBKMT2AMEN1 | |
| SCHEMBL28597596 | 0.66 | LCK (0.42) | ALDH1A1SMN1; SMN2NPC1RAB9AGLA | |
| SCHEMBL16085923 | 0.66 | SYK (0.38) | CCNE1CDK2GSK3BALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0337263-B1 | ISOXAZOL(ISOTHIAZOLS)-5-CARBOXAMIDES | BASF Aktiengesellschaft (DE) | 1993-03-17 | — | — | EP | disclosed |
| EP-0337263-A2 | Isoxazol(isothiazols)-5-carboxamides | BASF Aktiengesellschaft (DE) | 1989-10-18 | — | — | EP | disclosed |