Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.51 |
| ▸ | NPY1R | P25929 | 1/20 | 0.51 |
| ▸ | NPY2R | P49146 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10475455 | 0.89 | HPGD (0.49) | LMNANPY1RNPY2RNPC1RAB9A | |
| SCHEMBL7337123 | 0.88 | PDE3B (0.46) | LMNANPY1RNPY2RNPC1RAB9A | |
| SCHEMBL10723099 | 0.88 | HRH3 (0.48) | LMNANPC1RAB9ASMN1; SMN2PDE4B | |
| SCHEMBL10867608 | 0.85 | PDE4B (0.48) | LMNANPY1RNPY2RNPC1RAB9A | |
| SCHEMBL10474558 | 0.84 | BCHE (0.50) | LMNANPC1RAB9ASMN1; SMN2PDE4B | |
| SCHEMBL10475462 | 0.84 | MAPK1 (0.51) | LMNAHPGDALDH1A1MAPK1 | |
| SCHEMBL10431523 | 0.84 | HRH3 (0.51) | LMNASMN1; SMN2PDE4BPDE3BPDE3A | |
| SCHEMBL4884827 | 0.84 | LMNA (0.46) | LMNANPC1RAB9ASMN1; SMN2PDE4B | |
| SCHEMBL7326426 | 0.83 | PDE3B (0.47) | LMNANPY1RNPY2RNPC1RAB9A | |
| SCHEMBL7336275 | 0.83 | PDE3B (0.47) | LMNANPY1RNPY2RNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0330242-B1 | PYRIDAZINONE DERIVATIVES, THEIR PREPARATION AND USE | Sankyo Company Limited (JP) | 1993-09-22 | — | — | EP | disclosed |
| US-4914093-A | CARDIOVASCULAR DISORDERS | SANKYO COMPANY LIMITED (JP) | 1990-04-03 | — | — | US | disclosed |
| EP-0330242-A1 | Pyridazinone derivatives, their preparation and use | Sankyo Company Limited (JP) | 1989-08-30 | — | — | EP | disclosed |
| EP-0178189-A2 | Pyridazinone derivatives, their preparation and use | SANKYO COMPANY LIMITED (JP) | 1986-04-16 | — | — | EP | disclosed |