Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 7/20 | 0.62 |
| ▸ | HTR1B | P28222 | 7/20 | 0.62 |
| ▸ | HTR1A | P08908 | 1/20 | 0.62 |
| ▸ | NMT2 | O60551 | 1/20 | 0.48 |
| ▸ | NMT1 | P30419 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 2/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | HTR1F | P30939 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9526594 | 0.89 | HTR1D (0.77) | HTR1DHTR1BHTR1ANMT2NMT1 | |
| Hydrochloric Acid SCHEMBL9526972 | 0.88 | HTR1D (0.76) | HTR1DHTR1BHTR1ANMT2NMT1 | |
| SCHEMBL14186871 | 0.81 | HTR1B (0.77) | HTR1DHTR1BHTR1ANMT2NMT1 | |
| Naratriptan SCHEMBL68753 | 0.77 | HTR1D (1.00) | HTR1DHTR1BHTR1AAPPHTR6 | |
| Naratriptan SCHEMBL29403931 | 0.77 | HTR1D (1.00) | HTR1DHTR1BHTR1AAPPHTR6 | |
| SCHEMBL18409078 | 0.76 | APP (0.49) | HTR1DHTR1BHTR1ANMT2NMT1 | |
| Naratriptan SCHEMBL12803311 | 0.76 | HTR1D (0.98) | HTR1DHTR1BHTR1AAPPHTR6 | |
| Naratriptan SCHEMBL30903899 | 0.76 | HTR1D (0.98) | HTR1DHTR1BHTR1AAPPHTR6 | |
| Naratriptan SCHEMBL41527 | 0.76 | HTR1D (0.98) | HTR1DHTR1BHTR1AAPPHTR6 | |
| Naratriptan SCHEMBL28587084 | 0.76 | HTR1D (0.98) | HTR1DHTR1BHTR1AAPPHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0303507-B1 | INDOLE DERIVATIVES | GLAXO GROUP LTD (GB) | 1993-07-28 | — | — | EP | claimed |
| US-4997841-A | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1991-03-05 | — | — | US | claimed |
| EP-0303507-A2 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1989-02-15 | — | — | EP | claimed |
| EP-0303506-A2 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1989-02-15 | — | — | EP | claimed |
| EP-0303507-B1 | INDOLE DERIVATIVES | GLAXO GROUP LTD (GB) | 1993-07-28 | — | — | EP | disclosed |
| US-4997841-A | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1991-03-05 | — | — | US | disclosed |
| EP-0303507-A2 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1989-02-15 | — | — | EP | disclosed |