Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.34 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.30 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.30 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.30 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.30 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.30 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.30 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.30 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.30 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.30 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.30 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.30 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.30 |
| ▸ | CACNG1 | Q06432 | 1/20 | 0.30 |
| ▸ | CACNB2 | Q08289 | 1/20 | 0.30 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.30 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.30 |
| ▸ | CACNA1E | Q15878 | 1/20 | 0.30 |
| ▸ | CACNA2D4 | Q7Z3S7 | 1/20 | 0.30 |
| ▸ | CACNA2D3 | Q8IZS8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21359607 | 0.62 | MAP3K14 (0.33) | MAP3K14CACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL9528121 | 0.59 | CACNB4 (0.36) | MAP3K14CACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL10761977 | 0.59 | CACNB4 (0.36) | MAP3K14CACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL19598261 | 0.57 | MAP3K14 (0.33) | MAP3K14 | |
| SCHEMBL12474357 | 0.55 | SMN1; SMN2 (0.52) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL12877381 | 0.55 | CACNB4 (0.32) | MAP3K14CACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL13953393 | 0.55 | MAP3K14 (0.37) | MAP3K14 | |
| SCHEMBL5172854 | 0.55 | PARP1 (0.31) | MAP3K14 | |
| SCHEMBL83596 | 0.55 | — | — | |
| SCHEMBL1656999 | 0.55 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0220873-B1 | Fused bicyclic imides with psychotropic activity | AMERICAN HOME PROD (US) | 1993-11-24 | — | — | EP | disclosed |
| US-4892943-A | ANTIPSYCHOTIC, ANXIOLYTIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-01-09 | — | — | US | disclosed |
| EP-0220873-A1 | Fused bicyclic imides with psychotropic activity | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-05-06 | — | — | EP | disclosed |