Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 6/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.56 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.56 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9525550 | 1.00 | ACE (0.56) | ACEABCB11AGTR2PDE3ATDP1 | |
| SCHEMBL9526865 | 1.00 | ACE (0.56) | ACEABCB11AGTR2PDE3ATDP1 | |
| SCHEMBL9526877 | 1.00 | ACE (0.56) | ACEABCB11AGTR2PDE3ATDP1 | |
| SCHEMBL9526523 | 0.96 | ACE (0.52) | ACEABCB11AGTR2PDE3ATDP1 | |
| SCHEMBL9529543 | 0.92 | ACE (0.48) | ACEABCB11AGTR2PDE3ATDP1 | |
| SCHEMBL9530167 | 0.91 | ACE (0.54) | ACEABCB11AGTR2PDE3ATDP1 | |
| SCHEMBL10746240 | 0.90 | ACE (0.47) | ACEABCB11AGTR2PDE3ATDP1 | |
| SCHEMBL9526129 | 0.90 | ACE (0.47) | ACEABCB11AGTR2PDE3ATDP1 | |
| SCHEMBL10747879 | 0.90 | ACE (0.47) | ACEABCB11AGTR2PDE3ATDP1 | |
| SCHEMBL10746244 | 0.90 | ACE (0.47) | ACEABCB11AGTR2PDE3ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0365045-B1 | Perhydrothiazepine derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 1993-12-01 | — | — | EP | disclosed |
| EP-0365045-A1 | Perhydrothiazepine derivatives, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1990-04-25 | — | — | EP | disclosed |
| US-4699905-A | HYPOTENSIVE AGENTS | SANKYO COMPANY, LIMITED (JP) | 1987-10-13 | — | — | US | disclosed |
| EP-0161801-A2 | Perhydrothiazepine derivatives, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1985-11-21 | — | — | EP | disclosed |