Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 8/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HBB | P68871 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9527131 | 0.84 | CYP2D6 (0.37) | CYP2D6SLC6A2SLC6A4OPRM1OPRD1 | |
| SCHEMBL9526960 | 0.84 | CYP2D6 (0.37) | CYP2D6SLC6A2SLC6A4NR3C1ALDH1A1 | |
| SCHEMBL9527406 | 0.83 | SLC6A2 (0.41) | CYP2D6SLC6A2SLC6A4NR3C1ALDH1A1 | |
| SCHEMBL9526795 | 0.82 | CYP2D6 (0.36) | CYP2D6SLC6A2SLC6A4OPRM1OPRD1 | |
| Hydrochloric Acid SCHEMBL9526806 | 0.82 | CYP2D6 (0.36) | CYP2D6SLC6A2SLC6A4OPRM1OPRD1 | |
| SCHEMBL9526937 | 0.79 | CYP2D6 (0.35) | CYP2D6SLC6A2SLC6A4OPRM1OPRD1 | |
| SCHEMBL856897 | 0.74 | CYP2D6 (0.36) | CYP2D6SLC6A2SLC6A4OPRM1OPRD1 | |
| SCHEMBL856751 | 0.70 | MME (0.40) | ALDH1A1ADRA2AADRA2BADRA2CADRA1B | |
| SCHEMBL30645250 | 0.70 | MME (0.40) | ALDH1A1ADRA2AADRA2BADRA2CADRA1B | |
| SCHEMBL9530864 | 0.68 | LMNA (0.37) | CYP2D6SLC6A2SLC6A4OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0310745-B1 | SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR PREPARATION AND USE | ORION-YHTYMÄ OY (FI) | 1993-01-27 | — | — | EP | disclosed |
| EP-0183492-B1 | SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR PREPARATION AND USE | Farmos-Yhtyma Oy (FI) | 1989-11-15 | — | — | EP | disclosed |
| EP-0310745-A2 | Substituted imidazole derivatives and their preparation and use | ORION-YHTYMÄ OY (FI) | 1989-04-12 | — | — | EP | disclosed |
| US-4689339-A | 4-dihydroinden-2-yl-, 4-tetrahydronaphth-2-yl-, and 4-dihydrobenzofuran-2-ylimidazoles, useful to block α2 -adrenergic receptors | FARMOS YHTYMA OY (FI) | 1987-08-25 | — | — | US | disclosed |
| EP-0183492-A1 | Substituted imidazole derivatives and their preparation and use | Farmos-Yhtyma Oy (FI) | 1986-06-04 | — | — | EP | disclosed |