Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 12/20 | 0.78 |
| ▸ | HTR1B | P28222 | 12/20 | 0.78 |
| ▸ | HTR1A | P08908 | 2/20 | 0.78 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | THPO | P40225 | 1/20 | 0.58 |
| ▸ | HTR1F | P30939 | 1/20 | 0.54 |
| ▸ | APP | P05067 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | HTR6 | P50406 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9874795 | 0.99 | HTR1D (0.77) | HTR1DHTR1BHTR1ACYP1A2CYP3A4 | |
| SCHEMBL3222849 | 0.90 | HTR1D (0.77) | HTR1DHTR1BHTR1ACYP1A2CYP3A4 | |
| SCHEMBL23394791 | 0.90 | HTR1D (0.77) | HTR1DHTR1BHTR1ACYP1A2CYP3A4 | |
| SCHEMBL4541547 | 0.90 | HTR1D (0.77) | HTR1DHTR1BHTR1ACYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL9527429 | 0.89 | HTR1D (0.76) | HTR1DHTR1BHTR1ACYP1A2CYP3A4 | |
| SCHEMBL9874164 | 0.88 | HTR1D (0.68) | HTR1DHTR1BHTR1ACYP1A2CYP3A4 | |
| SCHEMBL9527534 | 0.88 | HTR1D (0.74) | HTR1DHTR1BHTR1ACYP1A2CYP3A4 | |
| Naratriptan SCHEMBL68753 | 0.88 | HTR1D (1.00) | HTR1DHTR1BHTR1ACYP1A2CYP3A4 | |
| SCHEMBL30137440 | 0.88 | HTR1D (0.74) | HTR1DHTR1BHTR1ACYP1A2CYP3A4 | |
| Naratriptan SCHEMBL29403931 | 0.88 | HTR1D (1.00) | HTR1DHTR1BHTR1ACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0382570-B1 | Indole derivatives | GLAXO GROUP LTD (GB) | 1993-12-08 | — | — | EP | claimed |
| CN-1058778-A | INDOLE DERIVATIVES | GLAXO GROP LTD (GB) | 1992-02-19 | — | — | CN | claimed |
| US-5001135-A | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1991-03-19 | — | — | US | claimed |
| JP-2300184-A | — | — | None | — | — | JP | disclosed |
| EP-0382570-B1 | Indole derivatives | GLAXO GROUP LTD (GB) | 1993-12-08 | — | — | EP | disclosed |
| CN-1058778-A | INDOLE DERIVATIVES | GLAXO GROP LTD (GB) | 1992-02-19 | — | — | CN | disclosed |
| US-5001135-A | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1991-03-19 | — | — | US | disclosed |
| JP-H02300184-A | INDOLE DERIVATIVE | GLAXO GROUP LTD | 1990-12-12 | — | — | JP | disclosed |
| EP-0382570-A1 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1990-08-16 | — | — | EP | disclosed |