Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 12/20 | 0.77 |
| ▸ | HTR1B | P28222 | 12/20 | 0.77 |
| ▸ | HTR1A | P08908 | 2/20 | 0.77 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | THPO | P40225 | 1/20 | 0.57 |
| ▸ | HTR1F | P30939 | 1/20 | 0.53 |
| ▸ | APP | P05067 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | HTR6 | P50406 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4541547 | 1.00 | HTR1D (0.77) | HTR1DHTR1BHTR1ACYP1A2CYP3A4 | |
| SCHEMBL9527477 | 0.90 | HTR1D (0.78) | HTR1DHTR1BHTR1ACYP1A2CYP3A4 | |
| SCHEMBL23394791 | 0.89 | HTR1D (0.77) | HTR1DHTR1BHTR1ACYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL9874795 | 0.89 | HTR1D (0.77) | HTR1DHTR1BHTR1ACYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL9527429 | 0.88 | HTR1D (0.76) | HTR1DHTR1BHTR1ACYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL9764720 | 0.88 | HTR1D (0.66) | HTR1DHTR1BHTR1ACYP1A2CYP3A4 | |
| SCHEMBL30137440 | 0.87 | HTR1D (0.74) | HTR1DHTR1BHTR1ACYP1A2CYP3A4 | |
| SCHEMBL9527534 | 0.87 | HTR1D (0.74) | HTR1DHTR1BHTR1ACYP1A2CYP3A4 | |
| Naratriptan SCHEMBL68753 | 0.87 | HTR1D (1.00) | HTR1DHTR1BHTR1ACYP1A2CYP3A4 | |
| Naratriptan SCHEMBL29403931 | 0.87 | HTR1D (1.00) | HTR1DHTR1BHTR1ACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009118753-A2 | PROCESS FOR PREPARATION OF NARATRIPTAN HYDROCHLORIDE | USV LIMITED (IN) | 2009-10-01 | — | — | WO | claimed |
| CN-1022243-C | Indole derivatives and process for preparation thereof | GLAXO GROUP LTD (GB) | 1993-09-29 | — | — | CN | claimed |
| EP-0303507-B1 | INDOLE DERIVATIVES | GLAXO GROUP LTD (GB) | 1993-07-28 | — | — | EP | claimed |
| US-4997841-A | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1991-03-05 | — | — | US | claimed |
| CN-1038807-A | The preparation method of indole derivatives | GLAXO GROUP LTD (GB) | 1990-01-17 | — | — | CN | claimed |
| EP-0303507-A2 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1989-02-15 | — | — | EP | claimed |
| EP-0303506-A2 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1989-02-15 | — | — | EP | claimed |
| WO-2009118753-A3 | PROCESS FOR PREPARATION OF NARATRIPTAN HYDROCHLORIDE | USV LIMITED (IN) | 2010-01-28 | — | — | WO | disclosed |
| WO-2009118753-A2 | PROCESS FOR PREPARATION OF NARATRIPTAN HYDROCHLORIDE | USV LIMITED (IN) | 2009-10-01 | — | — | WO | disclosed |
| WO-2009118753-A2 | PROCESS FOR PREPARATION OF NARATRIPTAN HYDROCHLORIDE | USV LIMITED (IN) | 2009-10-01 | — | — | WO | disclosed |
| US-20070059254-A1 | Compositions for delivering 5-ht agonists across the oral mucosa and methods of use thereof | TRANSORAL PHARMACEUTICALS, INC. (US) | 2007-03-15 | — | — | US | disclosed |
| US-20070059254-A1 | Compositions for delivering 5-ht agonists across the oral mucosa and methods of use thereof | TRANSORAL PHARMACEUTICALS, INC. (US) | 2007-03-15 | — | — | US | disclosed |
| EP-0639072-A1 | PHARMACEUTICAL COMPOSITIONS OF ALKYLSULPHONAMIDES 5HT1 AGONISTS FOR RECTAL ADMINISTRATION | LABORATOIRE GLAXO WELLCOME (FR) | 1995-02-22 | — | — | EP | disclosed |
| WO-1993021916-A1 | PHARMACEUTICAL COMPOSITIONS OF ALKYLSULPHONAMIDES 5HT1 AGONISTS FOR RECTAL ADMINISTRATION | LABORATOIRES GLAXO SA (FR) | 1993-11-11 | — | — | WO | disclosed |
| CN-1022243-C | Indole derivatives and process for preparation thereof | GLAXO GROUP LTD (GB) | 1993-09-29 | — | — | CN | disclosed |
| EP-0303507-B1 | INDOLE DERIVATIVES | GLAXO GROUP LTD (GB) | 1993-07-28 | — | — | EP | disclosed |
| US-4997841-A | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1991-03-05 | — | — | US | disclosed |
| CN-1038807-A | The preparation method of indole derivatives | GLAXO GROUP LTD (GB) | 1990-01-17 | — | — | CN | disclosed |
| EP-0303507-A2 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1989-02-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070059254-A1 | Compositions for delivering 5-ht agonists across the oral mucosa and methods of use thereof | HTR5A, HTR1A, HTR3A | HTR1D 17/4885HTR1B 15/4885HTR1A 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.